Evidence map›Paper›PMID 41593093›Full record

ArticleNature communications2026

ZFP57 is a regulator of postnatal growth and life-long health.

Geula Hanin, Boshra AlSulaiti, Kevin R Costello, Hugo Tavares, Nozomi Takahashi, Liudmila A Mikheeva, Anjuli Karmi Freeman, Shrina Patel, Benjamin Jenkins, Albert Koulman and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Geula HaninDepartment of Genetics, University of Cambridge, Cambridge, UK.ORCID 0000-0002-3198-7990
Boshra AlSulaitiDepartment of Genetics, University of Cambridge, Cambridge, UK.
Kevin R CostelloDepartment of Genetics, University of Cambridge, Cambridge, UK.
Hugo TavaresDepartment of Genetics, University of Cambridge, Cambridge, UK.ORCID 0000-0001-9373-2726
Nozomi TakahashiDepartment of Genetics, University of Cambridge, Cambridge, UK.
Liudmila A MikheevaDepartment of Genetics, University of Cambridge, Cambridge, UK.
Anjuli Karmi FreemanDepartment of Genetics, University of Cambridge, Cambridge, UK.
Shrina PatelDepartment of Genetics, University of Cambridge, Cambridge, UK.ORCID 0009-0003-0188-4936
Benjamin JenkinsCore Metabolomics and Lipidomics Laboratory, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Treatment Centre, University of Cambridge, Cambridge, UK.ORCID 0000-0002-3803-6418
Albert KoulmanCore Metabolomics and Lipidomics Laboratory, Wellcome-MRC Institute of Metabolic Science, Addenbrooke's Treatment Centre, University of Cambridge, Cambridge, UK.ORCID 0000-0001-9998-051X
Anne C Ferguson-SmithDepartment of Genetics, University of Cambridge, Cambridge, UK. afsmith@gen.cam.ac.uk.ORCID 0000-0002-7608-5894

Funding

Qatar National Research Fund (QNRF) GSRA8-I-1-0505-21030RCUK | Medical Research Council (MRC) MR/R009791/1RCUK | Medical Research Council (MRC) MR/W003783/1
6 · The paper itself

Abstract

Early-life factors, including postnatal nutrition, shape long-term health outcomes with epigenetic effects being implicated but poorly understood in the process. Zinc-finger protein 57 (ZFP57), is an epigenetic regulator of genomic imprinting, a process controlling gene expression based on parental origin with a vital role in prenatal growth. Here, we report an imprinting-independent function of ZFP57 in postnatal resource control via the mammary gland. ZFP57 influences multiple mammary gland phenotypes, including ductal branching and cellular homeostasis with its absence leading to significant differential gene expression related to alveologenesis and lactogenesis and altered milk composition. Zfp57

Indexed as

Mammary Glands, AnimalRepressor ProteinsAnimalsDNA-Binding ProteinsEpigenesis, GeneticFemaleGene Expression Regulation, DevelopmentalGenomic ImprintingLactationMiceMice, KnockoutDNA-Binding ProteinsRepressor ProteinsZfp-57 protein, mouse

Identifiers

PMID41593093
PMCPMC12953642

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.