ArticleTranslational psychiatry2026
Maternal cariprazine exposure effects on lactating offspring sterol biosynthesis.
Article in Translational psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
In the developing brain cholesterol is synthesized by both neurons and glia, and sterol biosynthesis peaks in early postnatal life. Genetic disruptions of sterol biosynthesis genes lead to complex intellectual and developmental disabilities. In addition, multiple commonly prescribed medications can impede sterol homeostasis. Of these, cariprazine (CAR) is one of the strongest prescription medications with sterol biosynthesis inhibiting side effects. CAR inhibits the final steps in cholesterol biosynthesis mediated by the enzyme dehydrocholesterol reductase 7 (DHCR7). This inhibition leads to accumulations of sterol precursors, including 7-dehydocholesterol (7-DHC). 7-DHC is the most oxidizable lipid known in mammals, and the 7-DHC derived oxysterols are toxic. There is limited information on CAR effects during lactation. We exposed lactating mice to daily CAR injections of 0.2 mg/kg CAR. At postnatal day 11 we found that CAR levels were similar in the brains of exposed pups and their lactating mothers. In addition, the exposed pup brains and livers had increased levels of 7-DHC and 8-DHC. This disruption of post-lanosterol sterol biosynthesis by CAR was not dependent on the sex of the pups or maternal genotype. However, CAR levels were genotype dependent, with Dhcr7
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