Evidence map›Paper›PMID 41593042›Full record

ArticleGut microbes2026

The enteric DNA virome differs in infants at risk for atopic disease.

Tyrus J Perdue, Cassandra E Newkirk, Robert Beblavy, Antti E Seppo, Erin C Davis, Michael B Sohn, Kirsi M Järvinen, Cynthia L Monaco

Abstract read
In one paragraph

Article in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tyrus J PerdueDepartment of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, United States.
Cassandra E NewkirkDepartment of Medicine, Division of Infectious Diseases, University of Rochester Medical Center, Rochester, NY, United States.ORCID 0009-0002-8004-6449
Robert BeblavyDepartment of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY, United States.
Antti E SeppoDivision of Allergy and Immunology, Center for Food Allergy, Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Golisano Children's Hospital, Rochester, NY, United States.
Erin C DavisDivision of Allergy and Immunology, Center for Food Allergy, Department of Pediatrics, University of Rochester School of Medicine and Dentistry, Golisano Children's Hospital, Rochester, NY, United States.ORCID 0000-0002-4599-1632
Michael B SohnDepartment of Biostatistics and Computational Biology, University of Rochester Medical Center, Rochester, NY, United States.ORCID 0000-0002-4981-8351
Kirsi M JärvinenDepartment of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, United States.ORCID 0000-0003-1548-6712
Cynthia L MonacoDepartment of Microbiology and Immunology, University of Rochester Medical Center, Rochester, NY, United States.ORCID 0000-0003-3093-5563

Funding

Training in Environment ToxicologyT32ES007026 · NIEHS · UNIVERSITY OF ROCHESTER · PI Alison Elder, Marissa Sobolewski Terry · 1985 to 2026
$20.2M
Impact of Maternal Diet and Supplements on Breast Milk CompositionU01AI131344 · NIAID · UNIVERSITY OF ROCHESTER · PI JARVINEN-SEPPO, KIRSI · 2017 to 2021
$3.0M
Influence of the Cervicovaginal Phageome on Health and Disease in Women Living with HIV.K08AI181643 · NIAID · UNIVERSITY OF ROCHESTER · PI Cynthia L. Monaco · 2024 to 2026
$589k
NIAID NIH HHS K08 AI181643NIAID NIH HHS U01 AI131344NIEHS NIH HHS T32 ES007026
6 · The paper itself

Abstract

Atopic disease prevalence, including atopic dermatitis, food allergy, asthma, and allergic rhinitis, has risen dramatically in industrialized countries. Traditional, single family farming lifestyles protect against atopic disease, but the mechanisms are incompletely understood. While there are established epidemiologic connections between childhood respiratory viral infections and the infant gut bacterial microbiome with allergic disease development, the influence of the early enteric virome on atopic disease development is unknown. We analyzed the enteric virome in 131 infants from high-atopy-risk urban/suburban environments and low-atopic-risk single-family farming communities. While similar at 12 months, enteric bacteriophage communities significantly differed by farm-life versus urban lifestyle at six weeks and six months of age. A lifestyle protective from atopic disease demonstrated higher colonization rates of

Indexed as

DNA VirusesGastrointestinal MicrobiomeHypersensitivity, ImmediateViromeBacteriophagesBifidobacteriumDNA, ViralFecesFemaleHumansInfantMaleDNA, ViralAtopic diseasebacteriophageenteric viromeinfantsphageome

Identifiers

PMID41593042
PMCPMC12851394

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.