Evidence map›Paper›PMID 41592914›Full record

ArticleRMD open2026

Proteomic footprint of serum urate concentration and urate transporter

Yuki Ohashi, Sahoko Ichihara, Ken Yamamoto, Yuki Kitamura, Tatsuaki Matsubara, Ruriha Beppo, Fumie Kinoshita, Tomoko S Kato, Yu Toyoda, Yusuke Kawamura and 4 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RMD open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00262691 (Investigation of Genetic Risk of Cardiovascular Disease in Prospective Cohort Study, the Kitanagoya Genome), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00262691 unknown statusnot on this map

Investigation of Genetic Risk of Cardiovascular Disease in Prospective Cohort Study, the Kitanagoya Genome (KING) Study for the Local Residents of Kitanagoya, Japan

TypeobservationalSponsorNagoya UniversityRan2005Enrolled7,000ConditionsHealthy, Coronary Disease, Myocardial Infarction, Cerebral Infarction
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Yuki OhashiPublic Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan.ORCID 0000-0002-7841-0566
Sahoko IchiharaDepartment of Environmental and Preventive Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan mnakatochi@met.nagoya-u.ac.jp saho@jichi.ac.jp.
Ken YamamotoDepartment of Medical Biochemistry, Kurume University School of Medicine, Kurume, Japan.
Yuki KitamuraDepartment of Environmental and Preventive Medicine, Jichi Medical University School of Medicine, Shimotsuke, Japan.
Tatsuaki MatsubaraFaculty of Human Sciences, Aichi Mizuho College, Nagoya, Japan.
Ruriha BeppoDepartment of Nursing, Nagoya University School of Health Sciences, Nagoya, Japan.
Fumie KinoshitaDepartment of Advanced Medicine, Data Science Division, Data Coordinating Center, Nagoya University Hospital, Nagoya, Japan.
Tomoko S KatoDivision of Cardio-Vascular Medicine, Kurume University School of Medicine, Kurume, Japan.
Yu ToyodaDepartment of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Japan.ORCID 0000-0002-7411-0531
Yusuke KawamuraDepartment of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Japan.
Hirotaka MatsuoDepartment of Integrative Physiology and Bio-Nano Medicine, National Defense Medical College, Tokorozawa, Japan.
Kimiyoshi IchidaSchool of Pharmacy, Tokyo University of Pharmacy and Life Sciences, Tokyo, Japan.
Mitsuhiro YokotaKurume University School of Medicine, Kurume, Japan.
Masahiro NakatochiPublic Health Informatics Unit, Department of Integrated Health Sciences, Nagoya University Graduate School of Medicine, Nagoya, Japan mnakatochi@met.nagoya-u.ac.jp saho@jichi.ac.jp.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExisting proteomic studies have primarily focused on gout flares or symptomatic hyperuricaemia, and few have comprehensively investigated circulating proteomic profiles in serum urate (SU) concentration as a continuous quantitative trait. This cross-sectional study investigated the association between SU concentration and serum proteomic profiles.

methodsWe enrolled 176 Japanese individuals aged ≥50 years and measured serum proteins using the Olink Explore 3072. To analyse the association between SU concentration and serum proteins, we applied linear regression adjusting for age, sex, renal function and insulin resistance with a false discovery rate threshold of 5%. Tissue-specific and gene set enrichment analyses were conducted based on the regression results.

resultsA total of 2886 proteins were analysed, among whom 63 showed significant associations with SU concentration; uromodulin demonstrated the strongest association (adjusted p=2.21×10

conclusionsTo the best of our knowledge, this is the first study to report a proteomic signature of SU concentration. These findings suggest that SU-associated proteomic signatures vary according to TRIAL REGISTRATION NUMBER: NCT00262691.

Indexed as

ATP Binding Cassette Transporter, Subfamily G, Member 2Neoplasm ProteinsPolymorphism, GeneticPolymorphism, Single NucleotideProteomicsUric AcidAgedBiomarkersCross-Sectional StudiesFemaleGoutHumansHyperuricemiaMaleMiddle AgedABCG2 protein, humanATP Binding Cassette Transporter, Subfamily G, Member 2BiomarkersNeoplasm ProteinsUric AcidEpidemiologyGoutPublic Health

Identifiers

PMID41592914
PMCPMC12853506

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.