Evidence map›Paper›PMID 41592889›Full record

ArticleJournal for immunotherapy of cancer2026

Tumor neoantigen gene C7orf50 remodels the immune microenvironment by recruiting tumor-associated macrophages to promote hepatocellular carcinoma progression and lung metastasis.

Jia Li, Xinming Ye, Sheng Su, Zhiqiang Hu, Changzhou Chen, Yu Gong, Zehuan Li, Feng Qi, Hecheng Li, Li Mao and 1 more

Abstract read
In one paragraph

Article in Journal for immunotherapy of cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jia Li *Key Laboratory of Carcinogenesis and Cancer Invasion, Zhongshan Hospital Fudan University, Shanghai, China.ORCID http://orcid.org/0009-0003-6312-3366
Xinming Ye *Key Laboratory of Carcinogenesis and Cancer Invasion, Zhongshan Hospital Fudan University, Shanghai, China.ORCID http://orcid.org/0009-0002-1023-8090
Sheng Su *Key Laboratory of Carcinogenesis and Cancer Invasion, Zhongshan Hospital Fudan University, Shanghai, China.
Zhiqiang Hu *Key Laboratory of Carcinogenesis and Cancer Invasion, Zhongshan Hospital Fudan University, Shanghai, China.
Changzhou ChenKey Laboratory of Carcinogenesis and Cancer Invasion, Zhongshan Hospital Fudan University, Shanghai, China.ORCID http://orcid.org/0000-0001-5396-3204
Yu GongKey Laboratory of Carcinogenesis and Cancer Invasion, Zhongshan Hospital Fudan University, Shanghai, China.
Zehuan LiKey Laboratory of Carcinogenesis and Cancer Invasion, Zhongshan Hospital Fudan University, Shanghai, China.
Feng QiDepartment of Oncology, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, China huang.xiaowu@zs-hospital.sh.cn sysuncml@163.com lihecheng2000@hotmail.com qf12486@rjh.com.cn.
Hecheng LiDepartment of Thoracic Surgery, Shanghai Jiao Tong University Medical School Affiliated Ruijin Hospital, Shanghai, China huang.xiaowu@zs-hospital.sh.cn sysuncml@163.com lihecheng2000@hotmail.com qf12486@rjh.com.cn.ORCID http://orcid.org/0000-0001-8069-6033
Li MaoKey Laboratory of Carcinogenesis and Cancer Invasion, Zhongshan Hospital Fudan University, Shanghai, China huang.xiaowu@zs-hospital.sh.cn sysuncml@163.com lihecheng2000@hotmail.com qf12486@rjh.com.cn.
Xiaowu HuangKey Laboratory of Carcinogenesis and Cancer Invasion, Zhongshan Hospital Fudan University, Shanghai, China huang.xiaowu@zs-hospital.sh.cn sysuncml@163.com lihecheng2000@hotmail.com qf12486@rjh.com.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundHepatocellular carcinoma (HCC) is a global health challenge with high mortality rates, particularly in patients with advanced disease and lung metastasis. T-cell receptor (TCR)-T cell therapy based on specific neoantigens, is an emerging treatment with potential for HCC. However, the prognosis of patients remains poor, underscoring the need for novel targets and strategies.

methodsWe conducted a comprehensive study to investigate the role of

resultsOur

conclusion

Indexed as

Antigens, NeoplasmCarcinoma, HepatocellularLiver NeoplasmsLung NeoplasmsTumor-Associated MacrophagesTumor MicroenvironmentAnimalsCell Line, TumorDisease ProgressionFemaleHumansMaleMiceAntigens, NeoplasmHepatocellular CarcinomaImmunotherapyMacrophageTumor microenvironment - TME

Identifiers

PMID41592889
PMCPMC12853547

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.