ArticleBMJ paediatrics open2026
Prevalence and severity of persistent pulmonary hypertension of the newborns among asphyxiated neonates admitted in Enugu State University Teaching Hospital.
Article in BMJ paediatrics open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPersistent pulmonary hypertension of newborns (PPHN) is an acute neonatal disorder with a high mortality rate despite several advances in its management.
designThis was a prospective cross-sectional study.
setting84 asphyxiated neonates were included. All the participants underwent complete transthoracic echocardiography to assess the parameters for the diagnosis of PPHN. PATIENT: Newborns with PPHN diagnosed via echocardiography with perinatal asphyxia who were admitted to the newborn unit.
interventionsEchocardiography was performed within 72 hours of life. The mean age at echocardiography was 38.4±0.71 hours.
main outcome measuresThe severity of asphyxia, gestational age and place of birth (inborn), delivery at the study centre or 'out-born' and delivery at another facility or location away from the study centre were significantly associated with the development of PPHN.
resultsThe prevalence of PPHN in the study was 52.4%. The severity of asphyxia, gestational age and place of birth (inborn), delivery at the study centre or 'out-born' and delivery at another facility or location away from the study centre were significantly associated with the development of PPHN (p<0.05). Severe asphyxia was approximately nine times more likely to be associated with the development of PPHN than mild asphyxia (AOR=9.89; 95% CI 1.92 to 50.94, p=0.006) and was the single most significant predictor of PPHN in the present study. However, the severity of asphyxia was not associated with the severity of PPHN. CONCLUSION AND RELEVANCE: Severe asphyxia was the single most significant predictor of the development of PPHN among asphyxiated neonates. The prevalence of PPHN among asphyxiated neonates was high. A high index of suspicion and the routine use of echocardiography and sildenafil to diagnose and treat PPHN in asphyxiated neonates are recommended.
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