Evidence map›Paper›PMID 41592787›Full record

ArticleVeterinary pathology2026

Pathology associated with human CAR T cell administration in NOD.Cg-

Renata M Mammone, Elinor Willis, Pedro Ruivo, Giovanni E Finesso, Arin Cox, Charles-Antoine Assenmacher, Enrico Radaelli, Alessandra Piersigilli, Ileana C Miranda

Abstract read
In one paragraph

Article in Veterinary pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Renata M MammoneMemorial Sloan Kettering Center, Weill Cornell Medicine, and The Rockefeller University, New York, NY.ORCID 0000-0003-1814-2392
Elinor WillisUniversity of Pennsylvania, Philadelphia, PA.ORCID 0000-0003-0588-9964
Pedro RuivoUniversity of California Davis School of Veterinary Medicine, California, CA.ORCID 0000-0002-5419-4790
Giovanni E FinessoUniversity of Pennsylvania, Philadelphia, PA.
Arin CoxUniversity of Pennsylvania, Philadelphia, PA.
Charles-Antoine AssenmacherUniversity of Pennsylvania, Philadelphia, PA.ORCID 0000-0003-0073-2730
Enrico RadaelliUniversity of Pennsylvania, Philadelphia, PA.ORCID 0000-0002-2885-0221
Alessandra PiersigilliMemorial Sloan Kettering Center, Weill Cornell Medicine, and The Rockefeller University, New York, NY.
Ileana C MirandaMemorial Sloan Kettering Center, Weill Cornell Medicine, and The Rockefeller University, New York, NY.ORCID 0000-0003-3168-0515

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI SELWYN M VICKERS · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Chimeric antigen receptor (CAR) T-cell therapy is a promising treatment for neoplasia and autoimmune diseases. Immunocompromised mice are a common model to test the efficacy and safety of CAR T cells of human origin. Preclinical toxicity associated with human CAR T-cell products encompasses a spectrum of morphologic changes, with currently limited documentation in the scientific literature. The purpose of this retrospective study was to characterize the histopathologic features associated with human CAR T-cell administration in immunodeficient NOD.Cg-

Indexed as

Immunotherapy, AdoptiveReceptors, Chimeric AntigenT-LymphocytesAnimalsDisease Models, AnimalFemaleGraft vs Host DiseaseHumansMiceMice, Inbred NODMice, SCIDRetrospective StudiesReceptors, Chimeric Antigencell therapychimeric antigen receptorimmunodeficient mouse modelNSGtranslational medicine

Identifiers

PMID41592787
PMCPMC13170698

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.