Evidence map›Paper›PMID 41592753›Full record

ArticleAmerican journal of physiology. Renal physiology2026

Hedgehog pathway disruption alters urothelial differentiation and continence mechanisms in the female mouse lower urinary tract.

Lindsey Felth Tanaka, Julia Tlapa, Jack Morrison, Tamryn Jordan, Monica Ridlon, Marcela Ambrogi, Jacob A Kracke-Bock, Annelise Resende, Madisyn Sierra Eyman, Conrad D Blosch and 4 more

Abstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lindsey Felth TanakaDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States.ORCID 0000-0002-7063-3976
Julia TlapaDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Jack MorrisonDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Tamryn JordanDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Monica RidlonDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States.ORCID 0000-0001-8605-4453
Marcela AmbrogiDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States.ORCID 0000-0001-6030-1129
Jacob A Kracke-BockDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Annelise ResendeBiomedical Research Model Services Breeding Core, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Madisyn Sierra EymanBiomedical Research Model Services Breeding Core, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Conrad D BloschBiomedical Research Model Services Breeding Core, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Jody PeterBiomedical Research Model Services Breeding Core, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Robert J LipinskiDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Walid FarhatDepartment of Urology, University of Wisconsin-Madison, Madison, Wisconsin, United States.
Kimberly P Keil StietzDepartment of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin, United States.ORCID 0000-0002-7006-9420

Funding

Role of Beta-Catenin in Urinary DysfunctionU54DK104310 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI RICKE, WILLIAM A · 2014 to 2023
$12.8M
Molecular & Environmental Toxicology Pre-& Postdoctoral Training ProgramT32ES007015 · NIEHS · UNIVERSITY OF WISCONSIN-MADISON · PI CHRISTOPHER A BRADFIELD · 1985 to 2026
$11.5M
Wisconsin Multidisciplinary K12 Urologic Research Career Development ProgramK12DK100022 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI CHAD M. VEZINA · 2013 to 2026
$8.6M
Developmental toxicity of pesticide synergist/Hedgehog inhibitor PBOR01ES026819 · NIEHS · UNIVERSITY OF WISCONSIN-MADISON · PI LIPINSKI, ROBERT · 2018 to 2022
$1.8M
Impact of developmental polychlorinated biphenyls on bladder contractilityR01ES035020 · NIEHS · UNIVERSITY OF WISCONSIN-MADISON · PI Kimberly Preston Keil Stietz · 2024 to 2026
$1.1M
Role of estrogen receptor beta in polychlorinated biphenyls impacts on bladder functionF31ES036876 · NIEHS · UNIVERSITY OF WISCONSIN-MADISON · PI Monica Ridlon · 2025 to 2026
$43k
HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK100022HHS | NIH | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) DK104310HHS | NIH | National Institute of Environmental Health Sciences (DEHS) ES007015HHS | NIH | National Institute of Environmental Health Sciences (DEHS) ES026819HHS | NIH | National Institute of Environmental Health Sciences (DEHS) ES035020HHS | NIH | National Institute of Environmental Health Sciences (DEHS) ES036876NIDDK NIH HHS K12 DK100022NIDDK NIH HHS U54 DK104310NIEHS NIH HHS F31 ES036876NIEHS NIH HHS R01 ES026819NIEHS NIH HHS R01 ES035020NIEHS NIH HHS T32 ES007015
6 · The paper itself

Abstract

Urinary incontinence (UI) imposes a significant healthcare burden and reduces quality of life. Contributing factors such as aging, pregnancy/childbirth, stress, and injury are recognized, but incomplete understanding of underlying mechanisms limits new therapies. Hedgehog (Hh) signaling has been implicated in lower urinary tract development, but its specific role in female continence mechanisms has not been fully characterized. Here we investigate the functional and molecular consequences of reduced Hh signaling using

Indexed as

Cell DifferentiationHedgehog ProteinsUrethraUrinary BladderUrinary IncontinenceUrotheliumAnimalsFemaleMiceMice, Inbred C57BLMuscle ContractionSerotonin Plasma Membrane Transport ProteinsSignal TransductionUrinationUrodynamicsZinc Finger Protein Gli2Gli2 protein, mouseHedgehog ProteinsSerotonin Plasma Membrane Transport ProteinsSlc6a4 protein, mouseZinc Finger Protein Gli2bladderincontinencesmooth muscle contractilityurothelium

Identifiers

PMID41592753
PMCPMC13037835

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.