Trial reportBrazilian journal of anesthesiology (Elsevier)
Impact of mannitol on intracranial pressure assessed by optic nerve sheath ultrasonography during video-laparoscopic prostatectomy: a randomized clinical trial.
Trial report in Brazilian journal of anesthesiology (Elsevier). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionIntracranial pressure can increase during video-laparoscopic prostatectomy due to the Trendelenburg position and pneumoperitoneum, potentially leading to complications. The Optic Nerve Sheath Diameter (ONSD) has emerged as a reliable, non-invasive method to assess ICP. Mannitol is commonly used to reduce ICP, but its intraoperative effects in this surgical setting remain unclear. This study aimed to evaluate the impact of mannitol administration on ICP, as assessed by ONSD.
methodsThis single-center, randomized, parallel-group, non-blinded clinical trial, 1:1 allocation, included 48 patients undergoing video-laparoscopic prostatectomy at a tertiary hospital in Brazil. Participants were randomly assigned to either the Mannitol Group, receiving 0.5 g.kg
resultsONSD increased in both groups between T1 and T3, followed by a reduction at T4. However, the decrease in ONSD in the Mannitol Group was not statistically significant compared to the Control Group. Regarding extubation, the mean extubation time was 24.04 ± 15.71 minutes in the Mannitol Group and 22.79 ± 15.37 minutes in the Control Group (p = 0.782).
conclusionMannitol administration during video-laparoscopic prostatectomy did not result in significant differences in ONSD trajectory or extubation time compared with the control group. At the dose and timing used, mannitol did not modify intraoperative surrogate measures of intracranial pressure.
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