Evidence map›Paper›PMID 41592564›Full record

ArticleCell reports. Medicine2026

An encyclopedia of the cord blood metabolome reveals maternal-fetal interactions and disease risk.

Samuel Lancaster, Samson Mataraso, Jonathan D Reiss, Kevin Contrepois, Casandra A Trowbridge, Basil Michael, Ian Simms, Matthew Ellenberger, Michelle Gibson, Max Clary and 18 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell reports. Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Samuel LancasterDepartment of Genetics, Stanford University School of Medicine, 240 Pasteur Drive, Palo Alto, CA 94304, USA.
Samson MatarasoDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA; Department of Biomedical Data Science, Stanford University School of Medicine, 1265 Welch Road, Stanford, CA 94305, USA; Department of Pediatrics, Stanford University School of Medicine, 725 Welch Road, Palo Alto, CA 94304, USA.
Jonathan D ReissDepartment of Pediatrics, Stanford University School of Medicine, 725 Welch Road, Palo Alto, CA 94304, USA.
Kevin ContrepoisDepartment of Genetics, Stanford University School of Medicine, 240 Pasteur Drive, Palo Alto, CA 94304, USA.
Casandra A TrowbridgeDepartment of Genetics, Stanford University School of Medicine, 240 Pasteur Drive, Palo Alto, CA 94304, USA.
Basil MichaelDepartment of Genetics, Stanford University School of Medicine, 240 Pasteur Drive, Palo Alto, CA 94304, USA.
Ian SimmsDepartment of Genetics, Stanford University School of Medicine, 240 Pasteur Drive, Palo Alto, CA 94304, USA.
Matthew EllenbergerDepartment of Genetics, Stanford University School of Medicine, 240 Pasteur Drive, Palo Alto, CA 94304, USA.
Michelle GibsonDepartment of Genetics, Stanford University School of Medicine, 240 Pasteur Drive, Palo Alto, CA 94304, USA.
Max ClaryDepartment of Genetics, Stanford University School of Medicine, 240 Pasteur Drive, Palo Alto, CA 94304, USA.
Lettie McGuireDepartment of Genetics, Stanford University School of Medicine, 240 Pasteur Drive, Palo Alto, CA 94304, USA.
Frank WongDepartment of Genetics, Stanford University School of Medicine, 240 Pasteur Drive, Palo Alto, CA 94304, USA.
Ethan CanfieldDepartment of Genetics, Stanford University School of Medicine, 240 Pasteur Drive, Palo Alto, CA 94304, USA.
Daniel CotterDepartment of Genetics, Stanford University School of Medicine, 240 Pasteur Drive, Palo Alto, CA 94304, USA.
Tao WangDepartment of Genetics, Stanford University School of Medicine, 240 Pasteur Drive, Palo Alto, CA 94304, USA.
Yan YangDepartment of Genetics, Stanford University School of Medicine, 240 Pasteur Drive, Palo Alto, CA 94304, USA.
Ramesh NairDepartment of Genetics, Stanford University School of Medicine, 240 Pasteur Drive, Palo Alto, CA 94304, USA.
Prabhakar KrishnanSchool of Computing, Amrita Vishwa Vidyapeetham University, Coimbatore, TN 641112, India.
P Venkat RanganAmrita Vishwa Vidyapeetham University, Coimbatore, TN 641112, India.
Ylayaly Katherine BiancoStanford University School of Medicine, Obstetrics & Gynecology - Maternal Fetal Medicine, 770 Welch Road, #201, Palo Alto, CA 94304, USA.
Jonathan A BernsteinDepartment of Pediatrics, Stanford University School of Medicine, 453 Quarry Road, Palo Alto, CA 94304, USA.
David K StevensonDepartment of Pediatrics, Stanford University School of Medicine, 725 Welch Road, Palo Alto, CA 94304, USA.
Tina CowanDepartment of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA.
Ekanath RanganDepartment of Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA.
Nima AghaeepourDepartment of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA; Department of Biomedical Data Science, Stanford University School of Medicine, 1265 Welch Road, Stanford, CA 94305, USA; Department of Pediatrics, Stanford University School of Medicine, 725 Welch Road, Palo Alto, CA 94304, USA.
Maya KasowskiDepartment of Genetics, Stanford University School of Medicine, 240 Pasteur Drive, Palo Alto, CA 94304, USA; Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA. Electronic address: kasowski@stanford.edu.
Karl G SylvesterDepartment of Surgery, Stanford University School of Medicine, 780 Welch Road, Palo Alto, CA 94304, USA. Electronic address: karls@stanford.edu.
Michael P SnyderDepartment of Genetics, Stanford University School of Medicine, 240 Pasteur Drive, Palo Alto, CA 94304, USA. Electronic address: mpsnyder@stanford.edu.

Funding

An Investigation of Omics for Bronchopulmonary DypslasiaK23HL173645 · NHLBI · STANFORD UNIVERSITY · PI JONATHAN REISS · 2025 to 2026
$385k
NHLBI NIH HHS K23 HL173645
6 · The paper itself

Abstract

Metabolites present in the mother traverse the placenta to supply energy, essential nutrients, and communication signals to the fetus. To gain a deeper understanding of fetal metabolism and the impacts of maternal metabolic health and medications on the fetus, we have created CordDB. Using mass spectrometry, we systematically document the metabolites and medications that enter and leave the fetus during birth, as well as the associated health records of the mother and newborn. These data reveal the metabolites consumed by the fetus, microbial metabolites (e.g., 3-indolepropionic acid), metabolites obtained from diet, and medications, as well as create a healthy newborn signature. Our study demonstrates that the mother's microbial interactions and nutrition, premature birth, and the mother's use of drugs such as bupivacaine and betamethasone are linked to variations in the metabolic profiles and health of newborns.

Indexed as

Fetal BloodMaternal-Fetal ExchangeMetabolomeFemaleHumansInfant, NewbornPlacentaPregnancybetamethasonefatty acidfetal metabolismmaternal metabolismmetabolomicsmicrobial metabolitesnewborn health signaturetaurineumbilical cord

Identifiers

PMID41592564
PMCPMC12923981

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.