ArticleAllergy, asthma & immunology research2026
Immune Profile After Oral Immunotherapy in Children With Persistent Cow's Milk Protein Allergy.
Article in Allergy, asthma & immunology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
purposeCow's milk protein allergy (CMPA) is the most common food allergy in childhood. Oral immunotherapy (OIT) has proven effective in achieving tolerance in children with persistent CMPA (pCMPA), although the underlying immunological mechanisms that allow for tolerance remain incompletely understood. We aimed to characterize the immune profile of pCMPA children following successful OIT and compare it to healthy controls (HC).
methodsThirty pCMPA children and 33 HC were recruited. T and B cell populations were assessed by flow cytometry, and specific immunoglobulins (sIgs) to milk allergens were measured by fluorometric enzyme-immunoassay.
resultsCompared to HC, pCMPA children showed reduced B cells and activated T cells. Activated CD4
conclusionsOIT modulates immune activation in pCMPA, reducing sIgE and increasing sIgG4 levels. Different relations between distinct sIgs and immune parameters may denote different stimulating and tolerance-inducing capacities for distinct cow's milk components. Age and time since OIT completion influence immune recovery, highlighting the complexity of tolerance mechanisms.
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