ArticleAllergy, asthma & immunology research2026
Genome-wide Association Study Identifies
Article in Allergy, asthma & immunology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePatients with asthma-chronic obstructive pulmonary disease (COPD) overlap (ACO) tend to have more severe respiratory symptoms than those with asthma or COPD only. In this study, we sought to identify genetic variants associated with ACO.
methodsACO was defined as patients with physician-diagnosed or self-reported asthma and COPD. Meta-analysis of genome-wide association studies (GWASs) of ACO was performed in non-Hispanic White (NHW: 4,292 ACO vs. 114,816 controls) and non-Hispanic Black or African American (NHB-AA: 2,335 ACO vs. 45,949 controls). Candidate genes for asthma or COPD were further pairwise compared among ACO, asthma, COPD, and control groups.
resultsThe prevalence rates of ACO/asthma/COPD were 2.46/8.89/3.57 (% of 200,369), 4.06/10.00/3.89 (% of 70,329), 1.40/10.21/1.40 (% of 6,093), and 0.43/4.55/0.58 (% of 12,783) for NHW, NHB-AA, Hispanic or Latino White, and non-Hispanic Asian, respectively. Patients with ACO or COPD and asthma were predominantly smokers and non-smokers, respectively. Patients with ACO showed highest blood eosinophil counts. Meta-analysis of GWASs identified rs1420101 (odds ratio [OR], 1.11;
conclusionsPrevalence of chronic respiratory diseases differs in racial/ethnic groups. On the basis of our phenotypic and genetic findings, we speculate that patients who carry asthma and COPD risk alleles, further influenced by smoking, may develop into ACO.
Indexed as
Identifiers
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Registered trials
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