ArticleAnalytical chemistry2026
IsoPS-DIA: Dual Functionality of Absolute Targeted Quantification and Global Proteome Profiling.
Article in Analytical chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Current gene testing reveals only the mutation status yet lacks protein expression of the actual drug target. A comprehensive evaluation requires methods that integrate the absolute quantification of mutant proteins with global profiling of downstream signaling and resistance pathways. Here, we present an isotope pair-separated data-independent acquisition (IsoPS-DIA) strategy with a dual functionality of multiplexed absolute quantification and global proteome profiling in a single run. IsoPS-DIA features a dual-window design: narrow consecutive windows separate light/heavy-isotope-labeled peptide pairs to reduce coisolation interference and maximize usable fragment ions, while wide variable windows capture proteome-wide information. Using
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