Evidence map›Paper›PMID 41592217›Full record

ArticleACS nano2026

Polyanion Chemistry Engineers Ternary RNA Nanoparticle Structure/Function from the Inside-Out.

Lijun Hu, David J Peeler, Tianyi Jin, James J Doutch, Baihao Shao, Jonathan Yeow, Li Ma, Hanna M G Barriga, Jiaqing Tang, Xuan Cao and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS nano, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Lijun HuKavli Institute for Nanoscience Discovery, Department of Physiology, Anatomy and Genetics, Department of Engineering Science, University of Oxford, Oxford OX1 3QU, United Kingdom.
David J PeelerKavli Institute for Nanoscience Discovery, Department of Physiology, Anatomy and Genetics, Department of Engineering Science, University of Oxford, Oxford OX1 3QU, United Kingdom.ORCID 0000-0003-2441-6409
Tianyi JinDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.ORCID 0000-0002-9974-2041
James J DoutchISIS Neutron and Muon Source, Harwell Campus, Oxford OX1 10QX, United Kingdom.ORCID 0000-0003-0747-8368
Baihao ShaoKavli Institute for Nanoscience Discovery, Department of Physiology, Anatomy and Genetics, Department of Engineering Science, University of Oxford, Oxford OX1 3QU, United Kingdom.
Jonathan YeowKavli Institute for Nanoscience Discovery, Department of Physiology, Anatomy and Genetics, Department of Engineering Science, University of Oxford, Oxford OX1 3QU, United Kingdom.ORCID 0000-0003-3709-5149
Li MaKavli Institute for Nanoscience Discovery, Department of Physiology, Anatomy and Genetics, Department of Engineering Science, University of Oxford, Oxford OX1 3QU, United Kingdom.
Hanna M G BarrigaDepartment of Medical Biochemistry and Biophysics, Karolinska Institute, Solna, Stockholm 171 77, Sweden.
Jiaqing TangKavli Institute for Nanoscience Discovery, Department of Physiology, Anatomy and Genetics, Department of Engineering Science, University of Oxford, Oxford OX1 3QU, United Kingdom.
Xuan CaoDepartment of Earth Sciences, University of Oxford, Oxford OX1 3AN, United Kingdom.
Chenchen LiuKavli Institute for Nanoscience Discovery, Department of Physiology, Anatomy and Genetics, Department of Engineering Science, University of Oxford, Oxford OX1 3QU, United Kingdom.
Christopher L GrigsbyDepartment of Medical Biochemistry and Biophysics, Karolinska Institute, Solna, Stockholm 171 77, Sweden.
Alfredo Alexander-KatzDepartment of Materials Science and Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States.
Robin J ShattockDepartment of Infectious Disease, Faculty of Medicine, Imperial College London, London SW7 2AZ, United Kingdom.
Molly M StevensKavli Institute for Nanoscience Discovery, Department of Physiology, Anatomy and Genetics, Department of Engineering Science, University of Oxford, Oxford OX1 3QU, United Kingdom.ORCID 0000-0002-7335-266X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Formulating cationic polyplexes (PP) with polyanions as ternary polyelectrolyte nanoparticles (TNP) offers a polymeric alternative to lipid nanoparticles (LNP) for targetable nucleic acid delivery. Although TNP

Indexed as

NanoparticlesPolyelectrolytesPolymersRNAHydrophobic and Hydrophilic InteractionsPolyethylene GlycolsPolyelectrolytesPolyethylene GlycolsPolymersRNAhigh throughputmolecular dynamicsPET-RAFTSANSself-amplifying RNAstructure/function

Identifiers

PMID41592217
PMCPMC12895518

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.