ArticleEmerging microbes & infections2026
Re-emergence of DENV-3 in Paraguay after two decades: a genomic and epidemiological investigation.
Article in Emerging microbes & infections, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Epidemiological and Evolutionary Dynamics of Dengue Virus in Saudi Arabia: Insights from Three Decades of Molecular and Serological Surveillance.International journal of molecular sciences · 2026Pooled it
- Analytical and Clinical Evaluation of the STANDARD M10 Arbovirus Panel for Dengue Detection, Serotyping, and Multiplex Arboviral Screening in the Americas.Diagnostics (Basel, Switzerland) · 2026Article
- Frequent introductions and climate suitability drive increasing dengue risk in Florida.medRxiv : the preprint server for health sciences · 2026Article
Corrections and comments
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Authors and funding
13 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Dengue is one of the most rapidly expanding mosquito-borne viral diseases worldwide, posing a persistent public health challenge across tropical and subtropical regions. Here, we report the re-emergence of dengue virus serotype 3 (DENV-3) in Paraguay following approximately 15 years without confirmed detection. In early 2025, twelve laboratory-confirmed cases were identified in the metropolitan region of Asunción through routine epidemiological surveillance and molecular diagnostics. To investigate the origin and evolutionary context of these infections, whole-genome sequencing and phylogenetic reconstruction were performed. Genomic analyses classified the viruses within DENV-3 genotype III, lineage B.3.2, supporting the hypothesis of a recent external introduction of an emerging lineage rather than persistence or renewed transmission of previously circulating local strains. Temporal and phylogeographic inferences further indicated recent introduction events consistent with regional viral movement across South America, highlighting the dynamic nature of dengue transmission in highly connected urban settings. These findings provide early evidence of DENV-3 re-establishment in Paraguay and emphasize the epidemiological relevance of continuous molecular surveillance, particularly in countries experiencing intense and recurrent dengue activity driven by multiple serotypes. Strengthening genomic monitoring frameworks is essential to enable rapid detection of lineage introductions, characterize transmission pathways, and support timely public health decision-making. Enhanced integration of genomic, epidemiological, and entomological data will be critical to anticipate outbreak risk and guide targeted control strategies aimed at reducing dengue burden in Paraguay and the broader region.
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