Evidence map›Paper›PMID 41591824›Full record

ArticleThe Journal of clinical investigation2026

Intraoperative arteriovenous patient sampling to assess in situ non-small cell lung cancer metabolism.

Johnathan R Kent, Keene L Abbott, Rachel Nordgren, Amy Deik, Nupur K Das, Millenia Waite, Tenzin Kunchok, Anna Shevzov-Zebrun, Nathaniel Christiansen, Amir Sadek and 9 more

Abstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical investigation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Johnathan R KentDepartment of Surgery, University of Chicago, Chicago, Illinois, USA.
Keene L AbbottDepartment of Biology and Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Rachel NordgrenDepartment of Public Health Sciences, University of Chicago, Chicago, Illinois, USA.
Amy DeikBroad Institute, Cambridge, Massachusetts, USA.
Nupur K DasDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA.
Millenia WaiteDepartment of Biology and Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Tenzin KunchokDepartment of Biology and Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Anna Shevzov-ZebrunDepartment of Biology and Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Nathaniel ChristiansenDepartment of Surgery, University of Chicago, Chicago, Illinois, USA.
Amir SadekDepartment of Surgery, University of Chicago, Chicago, Illinois, USA.
Darren S BryanDepartment of Surgery, University of Chicago, Chicago, Illinois, USA.
Mark K FergusonDepartment of Surgery, University of Chicago, Chicago, Illinois, USA.
Jessica S DoningtonDepartment of Surgery, University of Chicago, Chicago, Illinois, USA.
Alexander MuirBen May Department of Cancer Research, University of Chicago, Chicago, Illinois, USA.
Yatrik M ShahDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, Michigan, USA.
Clary B ClishBroad Institute, Cambridge, Massachusetts, USA.
Matthew G Vander HeidenDepartment of Biology and Koch Institute for Cancer Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.
Maria Lucia L MadariagaDepartment of Surgery, University of Chicago, Chicago, Illinois, USA.
Peggy P HsuDepartment of Internal Medicine, and.

Funding

Modeling and characterizing early ALK-dependent lung tumorigenesisK08CA286759 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Peggy Ping Hsu · 2025 to 2026
$325k
NCI NIH HHS K08 CA286759
6 · The paper itself

Abstract

Here authors report intraoperative sampling of blood entering and leaving the lung allowing direct assessment of nutrient use by lung cancer.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsAgedFemaleHumansMaleMiddle AgedGlucose metabolismLung cancerMetabolismMetabolomicsOncology

Identifiers

PMID41591824
PMCPMC12987651

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.