ArticleJournal of clinical monitoring and computing2026
Beyond the equation: transparency and verification in pharmacokinetic-pharmacodynamic model implementation for target-controlled infusion.
Article in Journal of clinical monitoring and computing, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Target concentrations of propofol predicted by four different pharmacokinetic/pharmacodynamic models to induce loss of consciousness in neurosurgical patients.Journal of anesthesia, analgesia and critical care · 2026Article
- Editor's note.Journal of clinical monitoring and computing · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent correspondence in the Journal of Clinical Monitoring and Computing has raised concerns about the transparency of implementing the Eleveld pharmacokinetic/pharmacodynamic model for propofol in commercial target-controlled infusion systems. While these models are scientifically robust, limited insight into software-level implementation may hinder independent verification and clinical confidence. Addressing this requires not only improved transparency and validation but also adequate clinician training, particularly as intravenous anesthesia techniques gain prominence in response to evolving regulatory and environmental pressures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.