Co-occurrence of Neuroleptic Malignant Syndrome and Silent Syndrome in a Patient With Bipolar Disorder: Clinical Challenges and Long-term Neurological Sequelae.

Buse Ceyran, Efruz Pirdogan Aydin, Burce Yucel, Derya Selcuk Demirelli

Abstract readCase Reports

In one paragraph

Article in Cerebellum (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Buse CeyranSisli Etfal Training and Research Hospital, Psychiatry Department, University of Health Sciences, Istanbul, Türkiye. ceyranbuse@gmail.com.ORCID http://orcid.org/0009-0008-0397-5037

Efruz Pirdogan AydinSisli Etfal Training and Research Hospital, Psychiatry Department, University of Health Sciences, Istanbul, Türkiye.

Burce YucelSisli Etfal Training and Research Hospital, Psychiatry Department, University of Health Sciences, Istanbul, Türkiye.

Derya Selcuk DemirelliSisli Etfal Training and Research Hospital, Neurology Department, University of Health Sciences, Istanbul, Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 31-year-old male with bipolar disorder on long-term lithium therapy presented to our emergency department with cerebellar and extrapyramidal signs, accompanied by fever and elevated creatine kinase levels. Cerebellar symptoms persisted for one year during follow-up. The patient was diag- nosed with Syndrome of Irreversible Lithium-Effectuated Neurotoxicity (SILENT) and concomitant neuroleptic malignant syndrome (NMS). This case highlights the rare coexistence of these serious complications, underscores the diagnostic and therapeutic challenges, and contributes to the litera- ture on clinical management.

Indexed as

Bipolar DisorderNeuroleptic Malignant SyndromeAdultAntimanic AgentsAntipsychotic AgentsHumansLithium CompoundsMaleAntimanic AgentsAntipsychotic AgentsLithium CompoundsAtaxiaLithium toxicityNeuroleptic malignant syndromeSILENT syndrome

Identifiers

PMID41591669

DOI10.1007/s12311-026-01959-7

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.