ArticleThe international journal of cardiovascular imaging2026
Right ventricular to pulmonary arterial uncoupling: clinical, functional and morphological insights in patients with hypertrophic cardiomyopathy.
Article in The international journal of cardiovascular imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Right ventricular (RV) to pulmonary arterial (PA) uncoupling measures RV exhaustion. There is limited evidence regarding the association between RV to PA coupling and hypertrophic cardiomyopathy (HCM). Evaluate RV to PA uncoupling in patients with HCM. Prospective cohort study in 62 patients with HCM without obstructive epicardial coronary disease. Echocardiography was used to assess RV to PA coupling as the ratio of tricuspid annular plane systolic excursion (TAPSE) to pulmonary artery systolic pressure (PASP). Coronary flow reserve in the left anterior descending artery (CVFR_LAD) was a surrogate marker for coronary microvascular dysfunction. Cardiopulmonary exercise testing (CPET) and cardiac magnetic resonance (CMR) were also performed. Mean age was 55 (15) years, 65% males. Mean TAPSE/PASP was 0.56 (0.23). The independent predictors of RV to PA coupling were age (β: - 0.184), left atrial volume index (β: - 0.641), CFVR_LAD (β: 0.183) and the extent of LGE in the LV (β: - 0.262). 43.5% showed reduced exercise tolerance. Independent predictors of peak VO2 were male gender (β: 0.349), age (β: - 0.286), global radial strain (β: 0.249) and TAPSE/PASP (β: 0.253). TAPSE/PASP showed a modest predictive accuracy for peak VO2 < 20 ml/Kg/min (AUC 0.671, p = 0.022), with the best cut-off set at 0.60 mm/mmHg (sensitivity 85% and specificity 47%). A TAPSE / PASP ≤ 0.60 mm/mmHg was present in 66% of patients. In patients with HCM, both coronary microvascular dysfunction and fibrosis are associated with RV to PA coupling, which is a determinant of exercise tolerance.
Indexed as
Identifiers
41591614What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.