ArticleHead and neck pathology2026
Intraductal Salivary Gland Neoplasms of the Oral Cavity: A Retrospective Case Series with Emphasis on Newly Described Entities.
Article in Head and neck pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeIntraductal salivary gland tumors represent a distinct and intriguing subset of salivary gland neoplasms, characterized by their origin within the ductal epithelium. These tumors encompass a wide range from benign entities such as intraductal papilloma to the malignant forms such as intraductal carcinoma (IDC). IDC often present as well-circumscribed mass due to their intraductal growth pattern, thereby mimicking benign neoplasms and posing diagnostic challenges. Recent advances have led to the molecular characterization of IDC, which may have been previously unrecognized or misclassified. This study aims to perform a comprehensive retrospective analysis of intraductal oral salivary gland neoplasms with a focus on reviewing newly described entities. MATERIALS AND
methodsFollowing institutional review board approval, archival biopsy records from 2000 to 2024 were reviewed for cases diagnosed as salivary ductal papilloma or IDC. Additional cases previously classified as papillary cystadenoma or adenocarcinoma, not otherwise specified, were re-evaluated for features consistent with IDC. Cases suspected of IDC were subjected to immunohistochemical analysis for p63, S100, and mammaglobin expression.
resultsThirty-five benign intraductal neoplasms were identified, which included sialadenoma papilliferum (SP) (n = 18, 31.40%), DP (n = 12, 34.30%), and inverted ductal papilloma (n = 5, 14.30%). The mean age of benign lesions was 66.5, with a slight male predominance. Most benign cases occurred on the buccal mucosa (n = 18, 51.4%). A total of seven IDC cases were identified, comprising three low-grade apocrine, two intercalated-like, one mixed phenotype, and one high-grade apocrine type. The mean age of the IDC cases was 58.6 years with a female predominance (n = 4, 66%), and most frequently occurred on the palate (n = 3, 42%).
conclusionIntraductal salivary gland neoplasms present diagnostic challenges due to their overlapping clinical and histologic features. Understanding of the characteristic morphologic and immunophenotypic profile of IDC is essential for accurate diagnosis and appropriate patient management.
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