Evidence map›Paper›PMID 41591554›Full record

Observational studyRheumatology international2026

Loneliness is associated with depression, anxiety, pain, and suffering in fibromyalgia: results from a structural equation modeling analysis.

Juan Pablo Román-Calderón, Camila Andrea Sánchez Salazar, José Hugo Arias Botero, Alicia Krikorian

Abstract readObservational Study
In one paragraph

Observational study in Rheumatology international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Juan Pablo Román-CalderónEAFIT University, Medellín, Colombia.ORCID http://orcid.org/0000-0002-4352-8513
Camila Andrea Sánchez SalazarFaculty of Medicine, CES University, Medellín, Colombia.ORCID http://orcid.org/0000-0001-9961-1722
José Hugo Arias BoteroFaculty of Medicine, CES University, Medellín, Colombia.ORCID http://orcid.org/0000-0002-4845-4752
Alicia KrikorianPain and Palliative Care Group, School of Health Sciences, Universidad Pontificia Bolivariana, Cq.1 No. 70-01, Medellín, Colombia. aliciakriko@gmail.com.ORCID http://orcid.org/0000-0003-2118-5692

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fibromyalgia is a widespread chronic pain condition affecting quality of life. Emotional distress and loneliness are factors commonly related to pain and suffering. However, no study has analyzed how all these variables interplay in individuals living with fibromyalgia. The study objective was to empirically test the relationships among loneliness, anxiety, depression, pain, and suffering in this population. Descriptive, observational, cross-sectional study. Structural equation modeling (SEM) was used to assess the relationships between loneliness, anxiety, and depression to the experience of pain and suffering in 317 fibromyalgia patients who attended a specialized pain management facility. Loneliness was positively associated with anxiety, pain, depression, and suffering. Moreover, in our sample, anxiety, depression, suffering, and pain demonstrated significant covariation. We also found that depression is positively related to pain and suffering. Our study demonstrates that loneliness in fibromyalgia is closely linked to anxiety, depression, pain, and suffering. Regular, comprehensive interventions that incorporate social support strategies may help reduce this burden.

Indexed as

AnxietyChronic PainDepressionFibromyalgiaLonelinessStress, PsychologicalAdultAgedCross-Sectional StudiesFemaleHumansLatent Class AnalysisMaleMiddle AgedQuality of LifeAnxietyChronic painDepressionFibromyalgiaLonelinessPainPsychological distress

Identifiers

PMID41591554
PMCPMC12847196

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.