Evidence map›Paper›PMID 41591526›Full record

ArticleSurgery today2026

Impact of CRM-oriented specimen processing on lymph node retrieval: a prospective multicenter study evaluating the risk of a suboptimal lymph node yield in rectal cancer.

Suguru Nukada, Manabu Shiozawa, Shota Izukawa, Yosuke Atsumi, Masahiro Asari, Keisuke Kazama, Yusuke Katayama, Koji Numata, Masakatsu Numata, Yo Mikayama and 5 more

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in Surgery today, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Suguru NukadaDepartment of Gastroenterological Surgery, Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan.
Manabu ShiozawaDepartment of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan. shiozawa.0m702@kanagawa-pho.jp.
Shota IzukawaDepartment of Gastroenterological Surgery, Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan.
Yosuke AtsumiDepartment of Surgery, Yokohama City University, Yokohama, Japan.
Masahiro AsariDepartment of Gastrointestinal Surgery, Kanagawa Cancer Center, Yokohama, Japan.
Keisuke KazamaDepartment of Surgery, Yokohama City University, Yokohama, Japan.
Yusuke KatayamaDepartment of Surgery, Japanese Red Cross Hadano Hospital, Hadano, Japan.
Koji NumataDepartment of Gastroenterological Surgery, Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan.
Masakatsu NumataDepartment of Gastroenterological Surgery, Gastroenterological Center, Yokohama City University Medical Center, Yokohama, Japan.
Yo MikayamaDepartment of Gastrointestinal Surgery, Kanagawa Prefectural Ashigarakami Hospital, Matsuda, Japan.
Akio HiguchiDepartment of Gastrointestinal Surgery, Yokohama Minami Kyousai Hospital, Yokohama, Japan.
Nobuhiro SuganoDepartment of Surgery, Hiratsuka Kyousai Hospital, Hiratsuka, Japan.
Teni GodaiDepartment of Surgery, Fujisawa Shonandai Hospital, Fujisawa, Japan.
Hiroyuki MushiakeDepartment of Surgery, Saiseikai Yokohamashi Nanbu Hospital, Yokohama, Japan.
Aya SaitoDepartment of Surgery, Yokohama City University, Yokohama, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThis prospective study evaluated the lymph node (LN) yield following CRM-oriented specimen processing, whilw paying particular attention to the proportion of cases with fewer than 12 examined LNs.

methodsThe Kanagawa Yokohama Colorectal Cancer Study Group conducted a multicenter prospective cohort study between 2021 and 2024. Patients with clinical stage II or III lower rectal cancer who underwent surgery without neoadjuvant therapy were enrolled in this study. This study reports a single-arm analysis of the short-term outcomes. Surgical specimens were processed using modified methods that preserved the mesentery adjacent to the tumor. The primary endpoint was the number of retrieved lymph nodes.

resultsThe median number of retrieved LNs was 19 (range, 2–98), and ≥ 12 LNs were identified in 81.6% of patients. CRM was assessable in 96.1% of the cases. Despite partial preservation of the mesorectum, the LN yield was not inferior to that reported in major clinical trials, and no systematic reduction attributable to the CRM-oriented methods was observed. Exploratory analyses suggested that patients with < 12 examined LNs were more frequently associated with patient- or procedure-related factors.

conclusionCRM-oriented specimen processing enables accurate CRM evaluation, while maintaining LN retrieval within a feasible range and preserving the clinically important threshold of ≥ 12 LNs.

Indexed as

Lymph Node ExcisionLymph NodesRectal NeoplasmsSpecimen HandlingAgedColorectal Surgical ProceduresFemaleHumansLymphatic MetastasisMaleMiddle AgedNeoplasm StagingProspective StudiesRiskCircumferential resection marginLymph nodesquasi-MERCURY methodRectal cancerStage migration

Identifiers

PMID41591526

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