Evidence map›Paper›PMID 41591515›Full record

ArticleOral and maxillofacial surgery2026

Distinguishing the indistinct: a comparative clinicopathologic and radiologic analysis of cemento-ossifying fibroma, psammomatoid ossifying fibroma, and juvenile trabecular ossifying fibroma".

Vivek Nayyar, Deepak Justine Viswanathan, Trupti Jain, Ashu Seith Bhalla, Smita Manchanda, Asit Ranjan Mridha, Ajoy Roychoudhury, Deepika Mishra

Abstract readComparative Study
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In one paragraph

Article in Oral and maxillofacial surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 · What the graph read from it

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3 · Its place in the literature

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1 citing paper in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Vivek NayyarDepartment of Oral Pathology and Microbiology, All India Institute of Medical Sciences, New Delhi, 110029, India.
Deepak Justine ViswanathanDepartment of Radiodiagnosis and Interventional Radiology, All India Institute of Medical Sciences, New Delhi, 110029, Delhi, India.
Trupti JainDepartment of Oral Pathology and Microbiology, All India Institute of Medical Sciences, New Delhi, 110029, India.
Ashu Seith BhallaDepartment of Radiodiagnosis and Interventional Radiology, All India Institute of Medical Sciences, New Delhi, 110029, Delhi, India.
Smita ManchandaDepartment of Radiodiagnosis and Interventional Radiology, All India Institute of Medical Sciences, New Delhi, 110029, Delhi, India.
Asit Ranjan MridhaDepartment of Pathology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.
Ajoy RoychoudhuryDepartment of Oral and Maxillofacial Surgery, All India Institute of Medical Sciences, New Delhi, 110029, India.
Deepika MishraDepartment of Oral Pathology and Microbiology, All India Institute of Medical Sciences, New Delhi, 110029, India. deepika1904@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBenign fibro-osseous lesions (BFOLs) of the jaws are characterized by the replacement of normal bone with fibrocellular stroma and mineralized material, including bone and cementum-like tissue. Their overlapping radiological and histopathological features often present diagnostic challenges. Recent WHO classifications have refined their categorization, highlighting the importance of distinguishing cemento-ossifying fibroma (COF), juvenile trabecular ossifying fibroma (JTOF), and psammomatoid ossifying fibroma (PsOF).

methodsA retrospective analysis of 24 cases (7 COF, 6 JTOF, 11 PsOF) diagnosed between 2020 and 2023 was conducted at a tertiary care center. Clinical, radiological, and histopathological data were reviewed by a multidisciplinary team. Radiographic patterns, histological features, and clinical outcomes were compared among the three entities.

resultsCOF predominantly affected adult females, presented mainly in the mandible, and showed a mixed radiolucent-radiopaque pattern with cementum-like calcifications. JTOF and PsOF occurred in younger patients, exhibited more aggressive behavior, and showed a male predominance in PsOF. JTOF presented with osteoid trabeculae lined by osteoblasts, while PsOF was characterized by psammomatoid bodies with osteoid rims and delicate, wispy eosinophilic collagen fibers at the periphery lacking osteoblastic rimming. Recurrence was not observed in any case during 4-56 months of follow-up following surgical treatment, which included enucleation with peripheral osteotomy or resection.

conclusionCOF, JTOF, and PsOF display distinct demographic, anatomical, and microscopic characteristics despite overlapping features. Accurate differentiation, aided by updated WHO classifications, is critical for optimal management. Recognizing these distinctions allows for appropriate surgical planning, reduces misdiagnosis, and prevents overtreatment.

Indexed as

CementomaFibroma, OssifyingJaw NeoplasmsAdolescentAdultChildDiagnosis, DifferentialFemaleHumansMaleRetrospective StudiesYoung AdultCemento-Ossifying fibromaJuvenile trabecular ossifying fibromaPsammomatoid ossifying fibroma

Identifiers

PMID41591515

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