Evidence map›Paper›PMID 41591459›Full record

ArticleArchives of microbiology2026

Synthesis of biocompatible novel multi-tailed indole-based resorcinarene for effective delivery of quercetin against multidrug-resistant S. aureus.

Khadija Rehman, Tasmina Kanwal, Muhammad Hasnain, Rukesh Maharjan, Wajeeha Muzafar, Komal Rao, Salim Saifullah, Shabana Usman Simjee, Muhammad Raza Shah

Abstract read
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Article in Archives of microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Khadija RehmanH.E.J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 74200, Pakistan.
Tasmina KanwalH.E.J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 74200, Pakistan.
Muhammad HasnainH.E.J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 74200, Pakistan.
Rukesh MaharjanH.E.J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 74200, Pakistan.
Wajeeha MuzafarH.E.J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 74200, Pakistan.
Komal RaoH.E.J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 74200, Pakistan.
Salim SaifullahH.E.J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 74200, Pakistan.
Shabana Usman SimjeeH.E.J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 74200, Pakistan.
Muhammad Raza ShahH.E.J Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 74200, Pakistan. raza.shah@iccs.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Resorcine-based macrocycles have received significant attention in drug delivery applications owing to their tunable functional groups, well-defined cavities, and inherent self-assembly behavior, considering essential for encapsulation and controlled release of loaded drug candidates. However, existing resorcinarene derivatives face certain limitations in drug loading, physiologic stability, and compatibility with structurally complex natural therapeutics, necessitating the development of novel macrocyclic architectures with improved stability and compatibility for hydrophobic drugs. To address this gap, the current research synthesized a novel resorcinarene-based macrocycle, referred to as Indole Macrocycle (IM), to improve the therapeutic potential of quercetin (QTN). The synthesized IM was characterized utilizing Mass,

Indexed as

Anti-Bacterial AgentsCalixarenesDrug CarriersIndolesMethicillin-Resistant Staphylococcus aureusPhenylalanineQuercetinAnimalsCell SurvivalDrug Delivery SystemsDrug Resistance, Multiple, BacterialMiceMicrobial Sensitivity TestsNIH 3T3 CellsAnti-Bacterial AgentsCalixarenesDrug CarriersIndolesPhenylalanineQuercetinresorcinareneAntibacterial activityIndole macrocycleQuercetinResorcinareneVesicles

Identifiers

PMID41591459

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.