Evidence map›Paper›PMID 41591454›Full record

ArticleClinical neuroradiology2026

Structural MRI Biomarkers of Intracranial Pressure in IIH: Linking Optic Nerve Sheath, Pituitary Morphology, and Hormonal Changes.

Zeynep Bendella, Barbara Daria Wichtmann, Ralf Clauberg, Wiebke Fenske, Charlotte Fries, Monika Jeub, Martina Minnerop, Arndt-Hendrik Schievelkamp, Franziskus M Schützeichel, Bettina Wabbels and 7 more

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Article in Clinical neuroradiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Zeynep BendellaDepartement of Neuroradiology, University of Bonn, Bonn, Germany. zeynep.bendella@ukbonn.de.
Barbara Daria WichtmannDepartement of Neuroradiology, University of Bonn, Bonn, Germany.
Ralf ClaubergDepartement of Neuroradiology, University of Bonn, Bonn, Germany.
Wiebke FenskeDepartment of Medicine, Endocrinology and Diabetes, BG University Hospital Bergmannsheil Bochum, Bochum, Germany.
Charlotte FriesDivision of Endocrinology, Diabetes and Metabolism, Department I for Internal Medicine, University of Bonn, Bonn, Germany.
Monika JeubDepartment of Neurology, University of Bonn, Bonn, Germany.
Martina MinneropInstitute of Neuroscience and Medicine (INM-1), Research Center Juelich, Juelich, Germany.
Arndt-Hendrik SchievelkampDepartment of Nuclear Medicine, University Hospital Cologne, Cologne, Germany.
Franziskus M SchützeichelDepartment of Ophthalmology, University of Bonn, Bonn, Germany.
Bettina WabbelsDepartment of Ophthalmology, University of Bonn, Bonn, Germany.
Christina SchaubDepartment of Neurology, University Hospital Knappschaftskrankenhaus Bochum, Bochum, Germany.
Max WitryDepartment of Neurology, University of Bonn, Bonn, Germany.
Berkan KoyakDepartment of Neurology, University of Bonn, Bonn, Germany.
Alexander RadbruchDepartement of Neuroradiology, University of Bonn, Bonn, Germany.
Jennifer LinderGerman Society of Intracranial Hypertension, Bad Honnef, Germany.
Ullrich WüllnerDepartment of Neurology, University of Bonn, Bonn, Germany.
Christine KindlerDepartment of Parkinson, Sleep and Movement disorders, University of Bonn, Bonn, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the relationship between intracranial pressure (ICP), anterior pituitary hormones, and structural brain changes in women with idiopathic intracranial hypertension (IIH).

methodsEighteen women with therapy-refractory IIH underwent lumbar puncture, endocrine assessment, and high-resolution brain MRI. Serum levels of pituitary hormones were correlated with ICP and radiological parameters including pituitary volume, flattening, and optic nerve (ON) and optic nerve sheath (ONS) volume. Group comparisons and partial correlations were used to evaluate associations.

resultsICP showed a significant positive association with thyroid-stimulating hormone (TSH) levels (r = 0.628, p = 0.016), and a significant negative association with growth hormone (GH) (r = -0.602, p = 0.023). Regarding structural parameters, only the volume of the right ON showed a strong positive association within the subgroup with elevated ICP (r = 0.90, p = 0.005). Correlations between ONS volumes and ICP in the normal pressure subgroup narrowly missed statistical significance. TSH was the only hormone showing a significant association, with higher TSH levels relating to larger pituitary volume in the normal ICP subgroup (r = 0.88, p = 0.020), but not in the elevated ICP subgroup.

conclusionOur exploratory findings suggest potential interactions between ICP, endocrine markers, and structural MRI measures. However, due to the limited sample size and variability in endocrine parameters, the results should be interpreted cautiously and considered hypothesis generating rather than clinically directive. Larger studies are needed to determine whether endocrine MRI associations hold true and whether they have diagnostic or clinical relevance.

Indexed as

Intracranial PressureMagnetic Resonance ImagingOptic NervePituitary GlandPseudotumor CerebriAdultBiomarkersFemaleHumansMiddle AgedThyrotropinBiomarkersThyrotropinGrowth hormoneHormone axesIdiopathic intracranial hypertensionIntracranial pressureOptic nerve sheathThyroid stimulating hormone

Identifiers

PMID41591454
PMCPMC13319219

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.