Evidence map›Paper›PMID 41591397›Full record

ArticleJournal of the American Chemical Society2026

Light-Driven Organocatalytic Birch Reduction for Late-Stage Drug Modification and sp

Florian Schiel, Luca di Martile, Roberta Coccia, Andrea Palone, Magdalena Medrzycka, Laura Kqiku, Paulo Neves, Nunzio Matera, Antonio Misale, Paolo Melchiorre

Abstract read
In one paragraph

Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Visible Light-Driven Copper-Catalyzed Asymmetric Synthesis via Sequential C(spAngewandte Chemie (International ed. in English) · 2026
    Article
  2. Energy-Transfer Catalysis Enables the Birch-Type Reduction of 2-Pyridones.Angewandte Chemie (International ed. in English) · 2026
    Article
  3. Multicomponent Photochemical Assembly of C(spACS organic & inorganic Au · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Florian SchielInstitute of Chemical Research of Catalonia, ICIQ, Av. Països Catalans 16, Tarragona 43007, Spain.
Luca di MartileDepartment of Industrial Chemistry 'Toso Montanari', University of Bologna, via Piero Gobetti 85, Bologna 40129, Italy.ORCID 0009-0006-2150-1885
Roberta CocciaDepartment of Industrial Chemistry 'Toso Montanari', University of Bologna, via Piero Gobetti 85, Bologna 40129, Italy.
Andrea PaloneDepartment of Industrial Chemistry 'Toso Montanari', University of Bologna, via Piero Gobetti 85, Bologna 40129, Italy.ORCID 0000-0001-8482-6085
Magdalena MedrzyckaDepartment of Industrial Chemistry 'Toso Montanari', University of Bologna, via Piero Gobetti 85, Bologna 40129, Italy.
Laura KqikuDepartment of Industrial Chemistry 'Toso Montanari', University of Bologna, via Piero Gobetti 85, Bologna 40129, Italy.
Paulo NevesJohnson & Johnson, In-Silico Discovery (ISD), Lisbon 2740-244, Portugal.ORCID 0000-0001-9556-6418
Nunzio MateraDepartment of Industrial Chemistry 'Toso Montanari', University of Bologna, via Piero Gobetti 85, Bologna 40129, Italy.ORCID 0009-0004-6506-7406
Antonio MisaleGlobal Discovery Chemistry, Johnson & Johnson, Calle Rio Jarama 75, Toledo 45007, Spain.
Paolo MelchiorreDepartment of Industrial Chemistry 'Toso Montanari', University of Bologna, via Piero Gobetti 85, Bologna 40129, Italy.ORCID 0000-0001-8722-4602

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Birch reduction is a cornerstone transformation in synthetic chemistry, yet its widespread application is limited by harsh conditions, poor functional group tolerance, and safety concerns. Recent photochemical strategies have offered milder alternatives but have largely been restricted to polycyclic arenes (

Indexed as

LightSpiro CompoundsCatalysisMolecular StructureOxidation-ReductionPhotochemical ProcessesSpiro Compounds

Identifiers

PMID41591397
PMCPMC12903859

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.