Evidence map›Paper›PMID 41591258›Full record

ArticleScience immunology2026

RORγt

Patrick Fernandes Rodrigues, Shitong Wu, Tihana Trsan, Bishan Bhattarai, Santosh K Panda, José Luís Fachi, Marina Cella, Marco Colonna

Abstract read
In one paragraph

Article in Science immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. ACY-1215 ameliorates experimental colitis by inhibiting dendritic cell maturation and Th1/Th17 responses.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Patrick Fernandes RodriguesDepartment of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.ORCID 0000-0002-0214-0627
Shitong WuDepartment of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.
Tihana TrsanDepartment of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.ORCID 0000-0002-7549-2885
Bishan BhattaraiDepartment of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.ORCID 0009-0003-1263-8554
Santosh K PandaDepartment of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.ORCID 0000-0001-8884-3050
José Luís FachiDepartment of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.ORCID 0000-0002-1035-5193
Marina CellaDepartment of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.ORCID 0000-0003-1230-1313
Marco ColonnaDepartment of Pathology and Immunology, Washington University School of Medicine in St. Louis, St. Louis, MO, USA.ORCID 0000-0001-5222-4987

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Pediatric Gastroenterology Research Training ProgramT32DK077653 · NIDDK · WASHINGTON UNIVERSITY · PI PHILLIP I TARR · 2007 to 2026
$5.8M
CIS-REGULATORY CIRCUITS FOR ILC FUNCTION AND PLASTICITYR01AI134035 · NIAID · WASHINGTON UNIVERSITY · PI MARCO COLONNA, Eugene M Oltz · 2018 to 2026
$4.8M
Mucosal Immune Defense Mechanisms of the Urinary BladderR01DK132327 · NIDDK · WASHINGTON UNIVERSITY · PI MARCO COLONNA, SCOTT J. HULTGREN · 2023 to 2026
$2.5M
MICROBIOTA-DEPENDENT CONTROL OF CLOSTRIDIUM DIFFICILE: THE ROLE OF ACETATE AND IL-22 BINDING PROTEINR01DK126969 · NIDDK · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2021 to 2024
$1.6M
Plasticity of Innate Lymphoid Cells: Mechanisms and Biological ImpactR01DK124699 · NIDDK · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2020 to 2023
$1.4M
NCATS NIH HHS UL1 TR002345NIAID NIH HHS R01 AI134035NIDDK NIH HHS R01 DK124699NIDDK NIH HHS R01 DK126969NIDDK NIH HHS R01 DK132327NIDDK NIH HHS T32 DK077653
6 · The paper itself

Abstract

How tolerogenic dendritic cell (DC) lineages are established to prevent inappropriate immune responses to commensals and food antigens remains unclear. We identified RORγt

Indexed as

Cell LineageDendritic CellsNuclear Receptor Subfamily 1, Group F, Member 3AnimalsCell DifferentiationMiceMice, Inbred C57BLMice, KnockoutT-Lymphocytes, RegulatoryNuclear Receptor Subfamily 1, Group F, Member 3Rorc protein, mouse

Identifiers

PMID41591258
PMCPMC13236574

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.