Evidence map›Paper›PMID 41591197›Full record

Observational studyToxins2026

Longitudinal, Multi-Cycle Evaluation of Passive Function Improvement in People with Arm Spasticity Treated with Botulinum Toxin A.

Stephen A Ashford, Khan Buchwald, Klemens Fheodoroff, Jorge Jacinto, Ajit Narayanan, Richard J Siegert, Christian Hannes, Lynne Turner-Stokes

Abstract readObservational StudyMulticenter Study
In one paragraph

Observational study in Toxins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Stephen A AshfordDepartment of Palliative Care, Policy and Rehabilitation, Cicely Saunders Institute, Florence Nightingale Faculty of Nursing, Midwifery and Palliative Care, King's College London, London SE5 9RS, UK.ORCID 0000-0001-5541-7063
Khan BuchwaldSchool of Clinical Sciences, Faculty of Health and Environmental Science, Auckland University of Technology, Auckland 0627, New Zealand.ORCID 0000-0002-9623-9723
Klemens FheodoroffNeurorehabilitation, Gailtal-Klinik, 9620 Hermagor, Austria.ORCID 0000-0002-6508-5055
Jorge JacintoCentro de Medicina de Reabilitaçãode Alcoitão, Serviço de Reabilitação de adultos 3, 2649-506 Estoril, Portugal.ORCID 0000-0002-3428-2312
Ajit NarayananSchool of Engineering, Computer and Mathematical Sciences, Auckland University of Technology, Auckland 1010, New Zealand.ORCID 0000-0003-3075-7672
Richard J SiegertDepartment of Psychology and Neuroscience, Faculty of Health and Environmental Science, Auckland University of Technology, Auckland 0627, New Zealand.
Christian HannesIpsen, 81677 Munich, Germany.
Lynne Turner-StokesDepartment of Palliative Care, Policy and Rehabilitation, Cicely Saunders Institute, Florence Nightingale Faculty of Nursing, Midwifery and Palliative Care, King's College London, London SE5 9RS, UK.ORCID 0000-0002-3302-9462

Funding

CSRD VA 1
6 · The paper itself

Abstract

Improvement in passive function (i.e., ease of caring for a limb) is a common goal for treatment of spasticity in the arm with botulinum toxin. A large international, observational, 2-year longitudinal study (ULIS-III, N = 953) was conducted in real-life practice. This original secondary analysis examines whether improvement in passive function goals were met over repeated injection cycles. We report changes by cycle measured by the Passive Function sub-scale of the Arm Activity measure (ArmA-PF) and examine predictors of improvement and injection occurrence. Inclusion in this analysis was based on passive function being selected as a primary or secondary goal for one or more cycle of treatment (

Indexed as

ArmBotulinum Toxins, Type AMuscle SpasticityNeuromuscular AgentsAdultAgedFemaleHumansLongitudinal StudiesMaleMiddle AgedTreatment OutcomeYoung AdultBotulinum Toxins, Type ANeuromuscular Agentsarm spasticitybotulinum toxingoal attainment scalingpassive functionreal-world evidencerehabilitationupper limb spasticity

Identifiers

PMID41591197
PMCPMC12845962

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.