Evidence map›Paper›PMID 41591192›Full record

ArticleToxins2026

Functional Dissection of

Chaitanya S Haram, Sebastian J Salinas, Coleman Wilson, Salma Waheed Sheikh, Kai Zhang, Peter A Keyel

Abstract read
In one paragraph

Article in Toxins, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chaitanya S HaramDepartment of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA.
Sebastian J SalinasDepartment of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA.
Coleman WilsonDepartment of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA.
Salma Waheed SheikhDepartment of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA.
Kai ZhangDepartment of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA.ORCID 0000-0002-6616-1806
Peter A KeyelDepartment of Biological Sciences, Texas Tech University, Lubbock, TX 79409, USA.ORCID 0000-0001-8637-8538

Funding

Phospholipid metabolism in LeishmaniaR15AI156746 · NIAID · TEXAS TECH UNIVERSITY · PI ZHANG, KAI · 2021 to 2024
$959k
National Institute of Allergy and Infectious Diseases R21AI156225NIAID NIH HHS R15 AI156746
6 · The paper itself

Abstract

Bacteria use cholesterol-dependent cytolysins (CDCs) to damage eukaryotes. While well-studied in mammals, the mechanisms by which CDCs bind to and kill protozoans remain unclear. CDCs bind to the human pathogen

Indexed as

Cell MembraneCholesterolCytotoxinsHemolysin ProteinsLeishmania majorAnimalsBacterial ProteinsBacterial ToxinsMetalloendopeptidasesProtozoan ProteinsStreptolysinsBacterial ProteinsBacterial ToxinsCholesterolClostridium perfringens theta-toxinCytotoxinsglycoprotein gp63, LeishmaniaHemolysin ProteinsMetalloendopeptidasesProtozoan Proteinsstreptolysin OStreptolysinscholesterol-dependent cytolysinsglycansLeishmania majormembrane defenseperfringolysinsterol accessibilitystreptolysin

Identifiers

PMID41591192
PMCPMC12846037

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.