Evidence map›Paper›PMID 41591056›Full record

ArticleNanomaterials (Basel, Switzerland)2026

Chemically Modified Zein- and Poly(methyl vinyl ether-co-maleic anhydride)-Based Core-Shell Sub-Micro/Nanoparticles for Essential Oil Delivery: Antibacterial Activity, Cytotoxicity, and Life Cycle Assessment.

Liudmyla Gryshchuk, Kyriaki Marina Lyra, Zili Sideratou, Fotios K Katsaros, Sergiy Grishchuk, Nataliia Hudzenko, Milena Násner, José Gallego, Léo Staccioli

Abstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Liudmyla GryshchukPS Resins GmbH, Lembergerstr. 94, 66955 Pirmasens, Germany.ORCID 0009-0005-7325-5754
Kyriaki Marina LyraInstitute of Nanoscience and Nanotechnology, National Centre of Scientific Research "Demokritos", Aghia Paraskevi, 15310 Attiki, Greece.
Zili SideratouInstitute of Nanoscience and Nanotechnology, National Centre of Scientific Research "Demokritos", Aghia Paraskevi, 15310 Attiki, Greece.ORCID 0000-0002-9314-2520
Fotios K KatsarosInstitute of Nanoscience and Nanotechnology, National Centre of Scientific Research "Demokritos", Aghia Paraskevi, 15310 Attiki, Greece.ORCID 0000-0003-2554-9799
Sergiy GrishchukDepartment of Applied Logistics and Polymer Sciences, Campus Pirmasens, Kaiserslautern University of Applied Sciences, Carl-Schurz-Str. 10-16, 66953 Pirmasens, Germany.
Nataliia HudzenkoLeibniz-Institut für Verbundwerkstoffe GmbH, Erwin-Schrödinger-Str. 58, 67663 Kaiserslautern, Germany.ORCID 0000-0003-2363-4527
Milena NásnerARDITEC Association, 48 Avenue Mont-Rabeau, 06200 Nice, France.ORCID 0000-0002-9982-9016
José GallegoARDITEC Association, 48 Avenue Mont-Rabeau, 06200 Nice, France.ORCID 0000-0001-8383-6388
Léo StaccioliARDITEC Association, 48 Avenue Mont-Rabeau, 06200 Nice, France.ORCID 0000-0002-7201-1302

Funding

HORIZON EUROPE Framework Programme 101057988
6 · The paper itself

Abstract

The threat of antimicrobial resistance (AMR) and the need for sustainable disinfectants have spurred interest in natural antimicrobials such as essential oils (EOs). However, their application is limited by volatility, poor water solubility, and cytotoxicity. Herein, we present the development of bio-based core-shell sub-micro-/nanocapsules (NCs) with encapsulated oregano (OO), thyme (TO), eucalyptus (EuO), and tea tree (TTO) oils to enhance antimicrobial (AM) performance and reduce cytotoxicity. NCs were synthesized via a nanoencapsulation method using chemically modified zein or poly(methyl vinyl ether-co-maleic anhydride) (GZA) as shell polymers, with selected EOs encapsulated in their core (encapsulation efficacy > 98%). Chemical modification of zein with vanillin (VA) and GZA with either dodecyl amine (DDA) or 3-(glycidyloxypropyl)trimethoxysilane (EPTMS) resulted in improvement in particle size distributions, polydispersity indices (PDIs) of synthesized NCs, and in the stability of the NC-dispersions in water. Antibacterial testing against

Indexed as

antimicrobialbio-based polymersessential oilslife cycle assessmentnanocapsulestoxicity

Identifiers

PMID41591056
PMCPMC12844389

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.