Evidence map›Paper›PMID 41590913›Full record

ArticleJournal of imaging2026

Ultrashort Echo Time Quantitative Susceptibility Source Separation in Musculoskeletal System: A Feasibility Study.

Sam Sedaghat, Jin Il Park, Eddie Fu, Annette von Drygalski, Yajun Ma, Eric Y Chang, Jiang Du, Lorenzo Nardo, Hyungseok Jang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Sam SedaghatDepartment of Diagnostic and Interventional Radiology, University Hospital Heidelberg, 69120 Heidelberg, Germany.ORCID 0000-0003-2804-3718
Jin Il ParkDepartment of Radiology, University of California, Davis, Sacramento, CA 95817, USA.ORCID 0000-0002-8763-4799
Eddie FuDepartment of Radiology, University of California, Davis, Sacramento, CA 95817, USA.
Annette von DrygalskiDepartment of Medicine, University of California, San Diego, San Diego, CA 92121, USA.
Yajun MaDepartment of Radiology, University of California, San Diego, San Diego, CA 92103, USA.
Eric Y ChangDepartment of Radiology, University of California, San Diego, San Diego, CA 92103, USA.ORCID 0000-0003-3633-5630
Jiang DuDepartment of Radiology, University of California, San Diego, San Diego, CA 92103, USA.ORCID 0000-0002-9203-2450
Lorenzo NardoDepartment of Radiology, University of California, Davis, Sacramento, CA 95817, USA.
Hyungseok JangDepartment of Radiology, University of California, Davis, Sacramento, CA 95817, USA.ORCID 0000-0002-3597-9525

Funding

Ultrashort Echo Time (UTE) Magnetic Resonance Imaging of BoneR01AR068987 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DU, JIANG · 2015 to 2024
$4.9M
Quantitative UTE MR Imaging: Sensitive Biomarkers for OsteoarthritisR01AR062581 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DU, JIANG · 2013 to 2022
$4.1M
Ultrashort Echo Time Magnetic Resonance Imaging of the Lumbar Intervertebral Disc.R01AR079484 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Yajun Ma · 2022 to 2026
$2.7M
Ultrashort Echo Time Magnetic Resonance Imaging of Hemophilic ArthropathyR01AR078877 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI JANG, HYUNGSEOK · 2021 to 2025
$2.4M
Quantitative UTE MR Imaging of Myelin: Novel Biomarkers for Alzheimer's DiseaseRF1AG075717 · NIA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DU, JIANG · 2022 to 2022
$2.3M
Three-dimensional Ultrashort Echo Time Magnetic Resonance Imaging of EnthesesR01AR075825 · NIAMS · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI CHANG, ERIC Y · 2019 to 2023
$1.8M
DFG SE 3272/6-1NIH HHS R01AR062581NIH HHS R01AR068987NIH HHS R01AR075825NIH HHS R01AR078877NIH HHS R01AR079484NIH HHS RF1AG075717University Heidelberg Project Expanding Internationality, Health Resources and Services Admin-istration H30MC24045VA Clinical Science Research and Development Services Merit Awards I01CX001388 and I01CX002211
6 · The paper itself

Abstract

This study aims to demonstrate the feasibility of ultrashort echo time (UTE)-based susceptibility source separation for musculoskeletal (MSK) imaging, enabling discrimination between diamagnetic and paramagnetic tissue components, with a particular focus on hemophilic arthropathy (HA). Three key techniques were integrated to achieve UTE-based susceptibility source separation: Iterative decomposition of water and fat with echo asymmetry and least-squares estimation for B0 field estimation, projection onto dipole fields for local field mapping, and χ-separation for quantitative susceptibility mapping (QSM) with source decomposition. A phantom containing varying concentrations of diamagnetic (CaCO

Indexed as

hemophilic arthropathyMRIQSMsource separationUTE

Identifiers

PMID41590913
PMCPMC12843048

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.