Evidence map›Paper›PMID 41590830›Full record

ArticleJournal of cardiovascular development and disease2025

Desmin-p.L112Q Disturbs Filament Formation and Is a Likely-Pathogenic Variant Associated with Dilated Cardiomyopathy.

Alexander Lütkemeyer, Sabrina Voß, Jonas Reckmann, Joline Groß, Anna Gärtner, Jan Gummert, Hendrik Milting, Andreas Brodehl

Abstract read
In one paragraph

Article in Journal of cardiovascular development and disease, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Alexander LütkemeyerClinic for Thoracic and Cardiovascular Surgery, Erich and Hanna Klessmann Institute, Heart and Diabetes Center North Rhine Westphalia, Ruhr-University Bochum, Georgstrasse 11, 32545 Bad Oeynhausen, Germany.ORCID 0009-0007-0959-1416
Sabrina VoßClinic for Thoracic and Cardiovascular Surgery, Erich and Hanna Klessmann Institute, Heart and Diabetes Center North Rhine Westphalia, Ruhr-University Bochum, Georgstrasse 11, 32545 Bad Oeynhausen, Germany.ORCID 0009-0007-6852-634X
Jonas ReckmannClinic for Thoracic and Cardiovascular Surgery, Erich and Hanna Klessmann Institute, Heart and Diabetes Center North Rhine Westphalia, Ruhr-University Bochum, Georgstrasse 11, 32545 Bad Oeynhausen, Germany.ORCID 0009-0005-5990-8368
Joline GroßClinic for Thoracic and Cardiovascular Surgery, Erich and Hanna Klessmann Institute, Heart and Diabetes Center North Rhine Westphalia, Ruhr-University Bochum, Georgstrasse 11, 32545 Bad Oeynhausen, Germany.ORCID 0009-0000-3347-9888
Anna GärtnerClinic for Thoracic and Cardiovascular Surgery, Erich and Hanna Klessmann Institute, Heart and Diabetes Center North Rhine Westphalia, Ruhr-University Bochum, Georgstrasse 11, 32545 Bad Oeynhausen, Germany.ORCID 0000-0001-6899-7693
Jan GummertClinic for Thoracic and Cardiovascular Surgery, Erich and Hanna Klessmann Institute, Heart and Diabetes Center North Rhine Westphalia, Ruhr-University Bochum, Georgstrasse 11, 32545 Bad Oeynhausen, Germany.
Hendrik MiltingClinic for Thoracic and Cardiovascular Surgery, Erich and Hanna Klessmann Institute, Heart and Diabetes Center North Rhine Westphalia, Ruhr-University Bochum, Georgstrasse 11, 32545 Bad Oeynhausen, Germany.ORCID 0000-0001-9722-0007
Andreas BrodehlClinic for Thoracic and Cardiovascular Surgery, Erich and Hanna Klessmann Institute, Heart and Diabetes Center North Rhine Westphalia, Ruhr-University Bochum, Georgstrasse 11, 32545 Bad Oeynhausen, Germany.ORCID 0000-0001-9202-2343

Funding

Deutsche Herzstiftung e. V. Plötzlicher HerztodErich and Hanna Klessmann Foundation EHKIMedical Faculty of the Ruhr-University Bochum FoRUM, F1074-2023 & F1099-24
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

cardiovascular geneticsdesmindesmosomesdilated cardiomyopathyintermediate filamentsmutations

Identifiers

PMID41590830
PMCPMC12842000

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.