Differential Expression of S100A Genes in hDPSCs Following Stimulation with Two Hydraulic Calcium Silicate Cements: A Laboratory Investigation.

Holger Jungbluth, Diana Lalaouni, Jochen Winter, Søren Jepsen, Dominik Kraus

Abstract read

In one paragraph

Article in Journal of functional biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Holger JungbluthDepartment of Periodontology, Operative and Preventive Dentistry, University Hospital, Faculty of Medicine, University of Bonn, Welschnonnenstr. 17, 53111 Bonn, Germany.ORCID 0000-0002-4836-5936

Diana LalaouniDepartment of Periodontology, Operative and Preventive Dentistry, University Hospital, Faculty of Medicine, University of Bonn, Welschnonnenstr. 17, 53111 Bonn, Germany.ORCID 0009-0008-3309-8442

Jochen WinterDepartment of Periodontology, Operative and Preventive Dentistry, University Hospital, Faculty of Medicine, University of Bonn, Welschnonnenstr. 17, 53111 Bonn, Germany.ORCID 0000-0001-8047-2099

Søren JepsenDepartment of Periodontology, Operative and Preventive Dentistry, University Hospital, Faculty of Medicine, University of Bonn, Welschnonnenstr. 17, 53111 Bonn, Germany.ORCID 0000-0002-4160-5837

Dominik KrausDepartment of Prosthodontics, Preclinical Education and Material Sciences, University Hospital, Faculty of Medicine, University of Bonn, Welschnonnenstr. 17, 53111 Bonn, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hydraulic calcium silicate cements (HCSCs) are contemporary materials in vital pulp therapy (VPT) and regenerative endodontic therapy (RET) due to their favorable effects on pulpal and periodontal cells, including cell differentiation and hard tissue formation. Recent studies also indicated the involvement of several S100A proteins in inflammatory, differentiation, and mineralization processes of the pulp. The aim of the present study was to investigate the effects of HCSCs on S100A gene expression in human dental pulp stem cells (hDPSCs). Human DPSCs were isolated and characterized by multi-lineage stem-cell markers and differentiation protocols. In stimulation experiments hDPSCs were exposed to ProRoot

Indexed as

hydraulic calcium silicate cementsS100A proteinsstem cellsvital pulp therapy

Identifiers

PMID41590823

DOI10.3390/jfb17010055

PMCPMC12843100

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.