Evidence map›Paper›PMID 41590820›Full record

ArticleJournal of functional biomaterials2026

Biomechanical Stimulation of Mesenchymal Stem Cells in 3D Peptide Nanofibers for Bone Differentiation.

Faye Fouladgar, Robert Powell, Emily Carney, Andrea Escobar Martinez, Amir Jafari, Neda Habibi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of functional biomaterials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Faye FouladgarBiomedical Engineering Department, University of North Texas, 3490 N Elm St., Denton, TX 76207, USA.
Robert PowellBiomedical Engineering Department, University of North Texas, 3490 N Elm St., Denton, TX 76207, USA.
Emily CarneyBiomedical Engineering Department, University of North Texas, 3490 N Elm St., Denton, TX 76207, USA.
Andrea Escobar MartinezBiomedical Engineering Department, University of North Texas, 3490 N Elm St., Denton, TX 76207, USA.
Amir JafariBiomedical Engineering Department, University of North Texas, 3490 N Elm St., Denton, TX 76207, USA.
Neda HabibiBiomedical Engineering Department, University of North Texas, 3490 N Elm St., Denton, TX 76207, USA.

Funding

National Institute of General Medical Science (NIGMS) R16GM150848
6 · The paper itself

Abstract

Mechanical stimulation critically regulates mesenchymal stem cell (MSC) differentiation, yet its effects in three-dimensional (3D) environments remain poorly defined. Here, we developed a custom dynamic stretcher integrating poly(dimethylsiloxane) (PDMS) chambers to apply cyclic strain to human MSCs encapsulated in Fmoc-diphenylalanine (Fmoc-FF) peptide hydrogels-a fully synthetic, tunable extracellular matrix mimic. Finite element modeling verified uniform strain transmission across the hydrogel. Dynamic stretching at 0.5 Hz and 10% strain induced pronounced cytoskeletal alignment, enhanced actin stress fiber formation (coherency index ≈ 0.85), and significantly increased proliferation compared to static or high-frequency (2.5 Hz, 1%) conditions (coherency index ≈ 0.6). Quantitative image analysis confirmed strain-dependent increases in coherency index and F-actin intensity, indicating enhanced mechanotransductive remodeling. Biochemical assays and qRT-PCR revealed 2-3-fold upregulation of osteogenic markers-

Indexed as

bone tissuedynamic stretchingmesenchymal stem cellsosteogenic differentiation

Identifiers

PMID41590820
PMCPMC12843260

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.