Evidence map›Paper›PMID 41590739›Full record

ArticleMarine drugs2026

Fucoidan Extracted from

Xiaoyu Song, Na Li, Xiujie Li, Bo Yuan, Xuan Zhang, Sheng Li, Xiaojing Yang, Bing Qi, Shixuan Yin, Chunxue Li and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Xiaoyu SongDepartment of Medical Physiology, School of Basic Medical Science, Dalian Medical University, Dalian 116044, China.
Na LiNational-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China.
Xiujie LiDepartment of Medical Physiology, School of Basic Medical Science, Dalian Medical University, Dalian 116044, China.
Bo YuanDepartment of Medical Physiology, School of Basic Medical Science, Dalian Medical University, Dalian 116044, China.
Xuan ZhangNational-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China.
Sheng LiNational-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China.
Xiaojing YangNational-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China.ORCID 0009-0004-2685-5602
Bing QiDepartment of Medical Physiology, School of Basic Medical Science, Dalian Medical University, Dalian 116044, China.
Shixuan YinDepartment of Medical Physiology, School of Basic Medical Science, Dalian Medical University, Dalian 116044, China.
Chunxue LiDepartment of Medical Physiology, School of Basic Medical Science, Dalian Medical University, Dalian 116044, China.
Yangting HuangDepartment of Medical Physiology, School of Basic Medical Science, Dalian Medical University, Dalian 116044, China.ORCID 0009-0003-8063-5486
Ben ZhangDepartment of Medical Physiology, School of Basic Medical Science, Dalian Medical University, Dalian 116044, China.
Yanjie GuoDepartment of Pathogen Biology and Microecology (Pathogen Biology Laboratory), School of Basic Medical Science, Dalian Medical University, Dalian 116044, China.
Jie ZhaoNational-Local Joint Engineering Research Center for Drug-Research and Development (R&D) of Neurodegenerative Diseases, Dalian Medical University, Dalian 116044, China.
Xuefei WuDepartment of Medical Physiology, School of Basic Medical Science, Dalian Medical University, Dalian 116044, China.

Funding

Liaoning Provincial Key R&D Program for Industrial Technology Innovation 2024JH2/102400054Open Project of National-Local Joint Engineering Research Center for Drug-Research and Devel-opment (R & D) of Neurodegenerative Diseases 2022GCYJZX-YB01Science and Technology Innovation Team Project of Liaoning Provincial Department of Education LJ222410161077The Innovation and Entrepreneurship Plan of Science and Technology Talent of Dalian 2022RG09
6 · The paper itself

Abstract

Fucoidan, a complex sulfated polysaccharide derived from marine brown seaweeds, exhibits broad biological activities, including anticoagulant, antitumor, antiviral, anti-inflammatory and lipid-lowering effects. Fucoidan confers neuroprotection in animal models of a broad spectrum of brain disorders such as Parkinson's disease (PD) and depression. However, the effect of fucoidan on gut-derived neuroinflammation and associated behavioral changes has been scarcely investigated. In comparison to fucoidan from other brown seaweeds, that from

Indexed as

AnxietyColitisColitis, UlcerativeFucusNeuroinflammatory DiseasesPolysaccharidesAnimalsAnti-Inflammatory AgentsBehavior, AnimalBlood-Brain BarrierBrainDextran SulfateDisease Models, AnimalMaleMiceMice, Inbred C57BLAnti-Inflammatory AgentsDextran SulfatefucoidanNeuroprotective AgentsPolysaccharidesDSSfucoidangut–brain axisIBDmicroglianeuroinflammation

Identifiers

PMID41590739
PMCPMC12843082

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.