Evidence map›Paper›PMID 41590717›Full record

ArticleMarine drugs2026

Onnamides A and B Suppress Hepatitis B Virus Transcription by Inhibiting Viral Promoter Activity.

Yasuhiro Hayashi, Sei Arizono, Nanami Higa, Trianda Ayuning Tyas, Yuichi Akahori, Kenji Maeda, Masaaki Toyama, Kanami Mori-Yasumoto, Mina Yasumoto-Hirose, Kei Miyakawa and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Marine drugs, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yasuhiro HayashiFaculty of Agriculture, University of Miyazaki, 1-1 Gakuen-kibanadai-nishi, Miyazaki City 889-2192, Miyazaki, Japan.
Sei ArizonoFaculty of Agriculture, University of Miyazaki, 1-1 Gakuen-kibanadai-nishi, Miyazaki City 889-2192, Miyazaki, Japan.
Nanami HigaFaculty of Science, University of the Ryukyus, 1 Senbaru, Nishihara City 903-0213, Okinawa, Japan.
Trianda Ayuning TyasFaculty of Science, University of the Ryukyus, 1 Senbaru, Nishihara City 903-0213, Okinawa, Japan.
Yuichi AkahoriDivision of Antiviral Therapy, Joint Research Center for Human Retrovirus Infection, Kagoshima University, 1-21-24 Korimoto, Kagoshima City 890-8544, Kagoshima, Japan.
Kenji MaedaDivision of Antiviral Therapy, Joint Research Center for Human Retrovirus Infection, Kagoshima University, 1-21-24 Korimoto, Kagoshima City 890-8544, Kagoshima, Japan.ORCID 0000-0002-9424-1491
Masaaki ToyamaDepartment of Virology II, National Institute of Infectious Diseases, Japan Institute for Health Security (JIHS), 1-23-1 Toyama, Shinjuku-ku, Tokyo 162-8640, Japan.
Kanami Mori-YasumotoFaculty of Pharmaceutical Sciences, Tokyo University of Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585, Japan.ORCID 0000-0002-9718-0823
Mina Yasumoto-HiroseTropical Technology Plus, 12-75 Suzaki, Uruma City 904-2234, Okinawa, Japan.
Kei MiyakawaInfluenza Research Center, National Institute of Infectious Diseases, Japan Institute for Health Security, 4-7-1 Gakuen, Musashimurayama City 208-0011, Japan.
Junichi TanakaFaculty of Science, University of the Ryukyus, 1 Senbaru, Nishihara City 903-0213, Okinawa, Japan.ORCID 0000-0002-8672-7379
Takahiro JomoriFaculty of Science, University of the Ryukyus, 1 Senbaru, Nishihara City 903-0213, Okinawa, Japan.ORCID 0000-0001-5866-0341

Funding

Kobayashi K2024-2025Okinawa Innovation Ecosystem Joint Research Promotion Project FT2023-2024
6 · The paper itself

Abstract

We recently reported that onnamide A, a marine-derived natural compound isolated from the sponge

Indexed as

Antiviral AgentsHepatitis B virusPromoter Regions, GeneticViral TranscriptionAnimalsCell Line, TumorHumansRNA, ViralTranscription, GeneticVirus ReplicationAntiviral AgentsRNA, Viralhepatitis B virusonnamides A and Bviral transcription inhibition

Identifiers

PMID41590717
PMCPMC12842730

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.