Can Fascaplysins Be Considered Analogs of Indolo[2,3-

Maxim E Zhidkov, Aleksandr M Popov, Olga A Soldatkina, Oleg A Tryapkin, Lyubov N Kharchenko

Abstract readComparative StudyReview

In one paragraph

Review in Marine drugs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

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0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Maxim E ZhidkovDepartment of Chemistry and Materials, Institute of High Technologies and Advanced Materials, FEFU Campus, Far Eastern Federal University, Ajax Bay 10, Russky Island, 690922 Vladivostok, Russia.

Aleksandr M PopovDepartments of Biotechnology and Marine Natural Compounds Chemistry, G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of The Russian Academy of Sciences, 690922 Vladivostok, Russia.

Olga A SoldatkinaDepartment of Chemistry and Materials, Institute of High Technologies and Advanced Materials, FEFU Campus, Far Eastern Federal University, Ajax Bay 10, Russky Island, 690922 Vladivostok, Russia.

Oleg A TryapkinDepartment of Chemistry and Materials, Institute of High Technologies and Advanced Materials, FEFU Campus, Far Eastern Federal University, Ajax Bay 10, Russky Island, 690922 Vladivostok, Russia.ORCID 0000-0001-8732-0055

Lyubov N KharchenkoDepartment of Chemistry and Materials, Institute of High Technologies and Advanced Materials, FEFU Campus, Far Eastern Federal University, Ajax Bay 10, Russky Island, 690922 Vladivostok, Russia.

Funding

Far Eastern Federal University development program "Priority 2030" ASP-25-02-1.04-0020Ministry of Science and Higher Education of the Russian Federation FZNS-2025-0010

6 · The paper itself

Abstract

For the first time, a comparative analysis has been conducted to elucidate the biosynthesis of three families of natural products-staurosporines/rebeccamycins, cladoniamides, and fascaplysins. Based on the available data, a well-founded hypothesis was formed that these metabolites arise through a shared biosynthetic pathway. A comparative evaluation of biological activity profiles and molecular mechanisms of action of the major representatives of these alkaloid families and their derivatives shows that, despite an apparent similarity between the activity spectra of indolo[2,3-

Indexed as

Biological ProductsCarbazolesIndolesAnimalsCarbolinesHumansIndolizinesQuaternary Ammonium CompoundsBiological ProductsCarbazolesCarbolinesfascaplysineIndolesIndolizinesQuaternary Ammonium Compoundsbiological activitybiosynthesisderivativesfascaplysinrebeccamycinsstaurosporines

Identifiers

PMID41590715

DOI10.3390/md24010018

PMCPMC12842986

What OpenQuestion holds

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LicenceCC BY

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.