Evidence map›Paper›PMID 41590703›Full record

ArticleMarine drugs2025

Enhanced Thermostability and Catalytic Efficiency of Alginate Lyase Alyw203 by Hydrogen Bond Network Reconstruction.

Chengcheng Jiang, Jing-Run Ye, Tian-Tian Zhu, Qin Wang, Yan Ma, Zhi-Peng Wang, Chuan-Yang Shi, Ying Wang, Shou-Fu Zhang, Tian-Hong Liu and 1 more

Abstract read
In one paragraph

Article in Marine drugs, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Chengcheng JiangKey Laboratory of Sustainable, Development of Polar Fishery, Ministry of Agriculture and Rural Affairs, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China.
Jing-Run YeSchool of Marine Science and Engineering, Qingdao Agricultural University, Qingdao 266109, China.
Tian-Tian ZhuKey Laboratory of Sustainable, Development of Polar Fishery, Ministry of Agriculture and Rural Affairs, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China.
Qin WangQingdao Institute of Marine Bioresources for Nutrition & Health Innovation, Qingdao 266106, China.
Yan MaSchool of Marine Science and Engineering, Qingdao Agricultural University, Qingdao 266109, China.
Zhi-Peng WangSchool of Marine Science and Engineering, Qingdao Agricultural University, Qingdao 266109, China.ORCID 0000-0001-9685-5801
Chuan-Yang ShiCollege of Food Science and Engineering, Ocean University of China, Qingdao 266003, China.
Ying WangMarine Science Research Institute of Shandong Province, Qingdao 266104, China.
Shou-Fu ZhangSchool of Marine Science and Engineering, Qingdao Agricultural University, Qingdao 266109, China.
Tian-Hong LiuMarine Science Research Institute of Shandong Province, Qingdao 266104, China.
Hai-Ying WangKey Laboratory of Sustainable, Development of Polar Fishery, Ministry of Agriculture and Rural Affairs, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Sciences, Qingdao 266071, China.ORCID 0000-0003-0737-4462

Funding

Central Public-interest Scientific Institute Basal Research Fund, CAFS 20603022024003Key R&D Program of Shandong Province, China 2023CXGC010414Natural Science Foundation of Shandong Province ZR2022MD084, ZR2022MC053, and ZR2022MC003Qingdao Shinan District Science and Technology Development Fund 2023-2-027-YYTaishan Scholars Program of Shandong Province tsqn202312277
6 · The paper itself

Abstract

Alginate lyases are commonly employed for producing alginate oligosaccharides (AOS), but their industrial application is often constrained by low thermal stability and catalytic efficiency. This study engineered mutants of alginate lyase Alyw203 from marine

Indexed as

Bacterial ProteinsPolysaccharide-LyasesVibrioAlginatesCatalysisEnzyme StabilityHydrogen BondingKineticsMolecular Dynamics SimulationMutationOligosaccharidesSubstrate SpecificityTemperatureAlginatesBacterial ProteinsOligosaccharidespoly(beta-D-mannuronate) lyasePolysaccharide-Lyasesalginate lyaseenzyme activityhydrogen bondsite-specific mutationthermal stability

Identifiers

PMID41590703
PMCPMC12843337

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.