Evidence map›Paper›PMID 41590670›Full record

ArticleMetabolites2026

Enhancing Caffeic Acid Production in

Qing Luo, Weihao Wang, Qingjing Huang, Chuan Wang, Lixiu Yan, Jun Kang, Jiamin Zhang, Jie Cheng

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qing LuoMeat Processing Key Laboratory of Sichuan Province, College of Food and Biological Engineering, Chengdu University, Chengdu 610106, China.
Weihao WangMeat Processing Key Laboratory of Sichuan Province, College of Food and Biological Engineering, Chengdu University, Chengdu 610106, China.
Qingjing HuangChongqing Academy of Metrology and Quality Inspection, Chongqing 401123, China.
Chuan WangChongqing Academy of Metrology and Quality Inspection, Chongqing 401123, China.
Lixiu YanChongqing Academy of Metrology and Quality Inspection, Chongqing 401123, China.
Jun KangThe Key Laboratory of Natural Products and Functional Food Development of Luzhou, Sichuan Vocational College of Chemical Technology, Luzhou 646005, China.
Jiamin ZhangMeat Processing Key Laboratory of Sichuan Province, College of Food and Biological Engineering, Chengdu University, Chengdu 610106, China.
Jie ChengChongqing Academy of Metrology and Quality Inspection, Chongqing 401123, China.ORCID 0000-0002-0500-4233

Funding

the Open Funding Project of Meat Processing Key Laboratory of Sichuan Province 24-R-02the Open Funding Project of the Key Laboratory of Natural Products and Functional Food Development of Luzhou 2024-GNSP-1
6 · The paper itself

Abstract

BACKGROUND/

objectivesCaffeic acid is a hydroxycinnamic acid that has a wide range of applications in the medical field. The synthesis of caffeic acid using microbial fermentation technology is an environmentally friendly method.

methodsBy engaging various enzymes, specifically 4-hydroxyphenylacetate 3-monooxygenase (HpaB), sourced from diverse bacterial strains, we successfully engineered a functional version of this enzyme within

resultsUnder shake-flask culture conditions, the highest yield of caffeic acid was achieved with an enzyme mixture containing HpaB from

Indexed as

caffeic acidHpaBsemi-rational designsubstrate flexibility

Identifiers

PMID41590670
PMCPMC12843657

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.