Antioxidant Clove Extract Inhibits Lipid Droplet Accumulation and Lipid Oxidation in Hepatocytes.

Satomi Monde, Dya Fita Dibwe, Shion Iwasaki, Shu-Ping Hui

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Article in Metabolites, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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Authors and funding

4 authors.

Satomi MondeGraduate School of Health Sciences, Hokkaido University, Kita-12, Nishi-5, Kita-Ku, Sapporo 060-0812, Japan.

Dya Fita DibweFaculty of Health Sciences, Hokkaido University, Kita-12, Nishi-5, Kita-Ku, Sapporo 060-0812, Japan.ORCID 0000-0003-3433-3834

Shion IwasakiGraduate School of Health Sciences, Hokkaido University, Kita-12, Nishi-5, Kita-Ku, Sapporo 060-0812, Japan.

Shu-Ping HuiFaculty of Health Sciences, Hokkaido University, Kita-12, Nishi-5, Kita-Ku, Sapporo 060-0812, Japan.ORCID 0000-0001-9973-6461

Funding

This study received funding from multiple sources at Hokkaido University, including the Startup Research Grant, Young Teacher Encouragement Grant (YTEG), and research grants from the Fac-ulty of Health Science. grant number 870411H and grant number 870412G

6 · The paper itself

Abstract

backgroundRecent studies have shown that plant-based dietary extracts can prevent the formation of lipid droplets (LDs) and oxidized lipid droplets (oxLDs) in liver cells. These results indicate that these extracts might be useful in addressing metabolic dysfunction-associated fatty liver disease (MAFLD) and its more severe form, metabolic dysfunction-associated steatohepatitis (MASH). In our ongoing study, we evaluated the potential of various food extracts to inhibit the accumulation and oxidation of LDs in liver cells to prevent metabolic MAFLD and MASH.

methodsThe antioxidant activity index was determined using the DPPH assay, cell viability was assessed via cytotoxicity and lipotoxicity, and lipid droplet accumulation inhibition (LDAI) assays were performed. Metabolome analysis was performed using 1D-NMR [

resultsDietary clove (

Indexed as

antioxidant activity indexbioactive compoundsfunctional foodslipid droplet accumulation inhibitionNMRnutraceuticalsplant metabolomicssecondary metabolites

Identifiers

PMID41590615

DOI10.3390/metabo16010007

PMCPMC12843948

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