ArticleMembranes2025
Cell Adhesion and Cytotoxicity Assessment of Collagen-Coated Electrospun PCL Membranes Functionalized with Silver Nanoparticles.
Article in Membranes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Multifunctional Oregano-Derived Plasma Polymer Coatings for Wound Healing Applications: An In Vitro Study.International wound journal · 2026Article
- Electrospun Fibers EncapsulatingMolecules (Basel, Switzerland) · 2026Article
- Bioinspired electrospun janus nanofibrous dressing for synergistic antibacterial activity and tissue regeneration.Frontiers in microbiology · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic and complex wounds require biomaterials that are both cytocompatible and antimicrobial. Herein, electrospun polycaprolactone (PCL) nanofiber membranes were coated with Type I collagen and functionalized with silver nanoparticles (AgNPs). The main objective was to assess fibroblast adhesion, proliferation, and cytotoxicity. Membrane morphology and surface characteristics were analyzed in a previous work by SEM, AFM, and wettability measurements, confirming the transformation from hydrophobic PCL to fully wettable collagen-coated surfaces. In this study, Murine 3T3 fibroblasts were cultured on PCL, PCL-Collagen, PCL-Collagen-Citrate, and PCL-Collagen-AgNPs membranes. Cellular activity was quantified using Alamar Blue assays at 24, 48, and 72 h, while cytotoxicity was determined by LDH release. Cellular viability and adhesion were studied using confocal microscopy. All membrane types supported fibroblast growth, with collagen-coated samples exhibiting the highest metabolic activity. AgNPs-functionalized membranes sustained overall cell viability above 90%, with cytotoxicity values of approximately 10% at 24 h and 20% at 48 h. Antimicrobial evaluations demonstrated complete inhibition of
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.