Evidence map›Paper›PMID 41590376›Full record

ArticleCurrent oncology (Toronto, Ont.)2026

Metastasis-Free Survival in Patients with Biochemical Recurrence After Robot-Assisted Radical Prostatectomy: A Multicenter, Retrospective Cohort Study in Japan (MSUG94 Group).

Minori Nezasa, Masayuki Tomioka, Tomoyuki Tatenuma, Takeshi Sasaki, Yoshinori Ikehata, Akinori Nakayama, Masahiro Toide, Tatsuaki Yoneda, Kazushige Sakaguchi, Kazuhide Makiyama and 6 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Current oncology (Toronto, Ont.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Minori NezasaDepartment of Urology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
Masayuki TomiokaDepartment of Urology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.
Tomoyuki TatenumaDepartment of Urology, Yokohama City University, Yokohama 236-0004, Japan.
Takeshi SasakiDepartment of Nephro-Urologic Surgery and Andrology, Mie University Graduate School of Medicine, Tsu 514-8507, Japan.ORCID 0000-0002-2458-5686
Yoshinori IkehataDepartment of Urology, University of Toyama, Toyama 930-0194, Japan.
Akinori NakayamaDepartment of Urology, Dokkyo Medical University Saitama Medical Center, Koshigaya 343-8555, Japan.
Masahiro ToideDepartment of Urology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo 113-8677, Japan.
Tatsuaki YonedaDepartment of Urology, Seirei Hamamatsu General Hospital, Hamamatsu 430-8558, Japan.ORCID 0009-0003-1849-2883
Kazushige SakaguchiDepartment of Urology, Toranomon Hospital, Tokyo 105-8470, Japan.ORCID 0000-0001-7065-9378
Kazuhide MakiyamaDepartment of Urology, Yokohama City University, Yokohama 236-0004, Japan.ORCID 0000-0002-7449-2015
Takahiro InoueDepartment of Nephro-Urologic Surgery and Andrology, Mie University Graduate School of Medicine, Tsu 514-8507, Japan.
Hiroshi KitamuraDepartment of Urology, University of Toyama, Toyama 930-0194, Japan.ORCID 0000-0002-1592-931X
Kazutaka SaitoDepartment of Urology, Dokkyo Medical University Saitama Medical Center, Koshigaya 343-8555, Japan.
Fumitaka KogaDepartment of Urology, Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital, Tokyo 113-8677, Japan.ORCID 0000-0001-7888-0085
Shinji UrakamiDepartment of Urology, Seirei Hamamatsu General Hospital, Hamamatsu 430-8558, Japan.
Takuya KoieDepartment of Urology, Gifu University Graduate School of Medicine, Gifu 501-1194, Japan.ORCID 0000-0002-2980-127X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Robot-assisted radical prostatectomy (RARP) is the definitive surgical treatment for localized prostate cancer (PCa). Some patients with post-RARP biological recurrence (BCR) eventually develop distant metastases and subsequent PCa-related mortality. The objective of this study was to clarify the predictive factors for the risk of metastatic disease after BCR in patients with PCa who underwent RARP. This multicenter retrospective cohort study was conducted in nine Japanese institutions and enrolled 491 men with BCR, detected between 2011 and 2024. During the median 59-month follow-up period, 44 patients (9.0%) had radiological confirmation of distant metastasis. Patients with developed metastases after BCR exhibited higher biopsy Gleason grade and pathological T stage, increased lymphovascular invasion (LVI) in the surgical specimen, and a shorter interval from RARP to BCR. In univariate analysis, LVI and a time to BCR after RARP of ≤14.9 months were significant predictors of distant metastasis. In the multivariate analysis, LVI constituted a significant independent predictor of distant metastasis (

Indexed as

Neoplasm Recurrence, LocalProstatectomyProstatic NeoplasmsRobotic Surgical ProceduresAgedDisease-Free SurvivalHumansJapanMaleMiddle AgedNeoplasm MetastasisRetrospective Studiesbiochemical recurrencelymphovascular invasionmetastasis-free survivalprostate cancerrobot-assisted radical prostatectomy

Identifiers

PMID41590376
PMCPMC12839879

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.