ArticleCurrent oncology (Toronto, Ont.)2025
Low HALP Score Predicts Prolonged Hospitalization in Solid Tumor Patients with Febrile Neutropenia.
Article in Current oncology (Toronto, Ont.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- The Association Between the HALP Score and Glycemic Control in Older Adults with Type 2 Diabetes Mellitus Receiving Home Health Care.Healthcare (Basel, Switzerland) · 2026Article
- Predictors of Hospitalization due to Febrile Neutropenia in Cancer Patients Receiving Chemotherapy.Cancer medicine · 2026Observational
- Evaluation of the Relationship Between the Pan-Immune-Inflammation Score and the Systemic Immune-Inflammation Index and Hypertension: A Retrospective Cross-Sectional Study.Journal of clinical medicine · 2026Article
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2 authors.
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Abstract
backgroundFebrile neutropenia (FN) is a serious chemotherapy-related complication in patients with solid tumors. Identifying simple and accessible biomarkers that can predict prolonged hospitalization may support early risk stratification and clinical decision-making.
methodsThis retrospective study included 169 adults hospitalized with FN between January 2023 and January 2025. Immunonutritional indices, including the Hemoglobin-Albumin-Lymphocyte-Platelet (HALP) score, the Prognostic Nutritional Index (PNI), and the C-reactive protein/albumin ratio (CAR), as well as the Clinical Index of Stable Febrile Neutropenia (CISNE) score were calculated. HALP and PNI were categorized using ROC-derived cut-offs based on the Youden Index. Prolonged hospital stay was defined as a binary variable based on the cohort median (>9 days). Spearman correlation, univariate and multivariate logistic regression were performed to identify predictors of prolonged hospitalization.
resultsHALP showed a significant negative correlation with hospitalization duration (r = -0.469;
conclusionsA Low HALP score, higher CISNE risk categories, and microbiological culture positivity independently predicted prolonged hospitalization in FN. HALP, as a simple and inexpensive immunonutritional marker, may enhance early FN risk assessment when used alongside validated clinical tools such as CISNE or MASCC.
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