Evidence map›Paper›PMID 41590218›Full record

ArticleDiseases (Basel, Switzerland)2025

The Impact of Proactive Fecal Calprotectin Collection in an Outreach Protocol for Biologic-Naïve Ulcerative Colitis Patients-Ulcerative Colitis Clinical Outreach (UCCO).

Scott MacKay, Denise Parsons, Candace Hagerman, Ellina Lytvyak, Levinus Dieleman, Frank Hoentjen, Karen Kroeker, Farhad Peerani, Karen Wong, Michal Gozdzik and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diseases (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Scott MacKayDivision of Gastroenterology, University of Alberta, Edmonton, AB T6G 2X8, Canada.ORCID 0009-0000-8069-7060
Denise ParsonsDivision of Gastroenterology, University of Alberta, Edmonton, AB T6G 2X8, Canada.ORCID 0000-0002-2478-9574
Candace HagermanDivision of Emergency Medicine, University of Alberta, Edmonton, AB T6G 2X8, Canada.
Ellina LytvyakDivision of Preventive Medicine, University of Alberta, Edmonton, AB T6G 2X8, Canada.ORCID 0000-0001-5651-9010
Levinus DielemanDivision of Gastroenterology, University of Alberta, Edmonton, AB T6G 2X8, Canada.
Frank HoentjenDivision of Gastroenterology, University of Alberta, Edmonton, AB T6G 2X8, Canada.ORCID 0000-0001-5314-4452
Karen KroekerDivision of Gastroenterology, University of Alberta, Edmonton, AB T6G 2X8, Canada.ORCID 0000-0002-3886-4213
Farhad PeeraniDivision of Gastroenterology, University of Alberta, Edmonton, AB T6G 2X8, Canada.ORCID 0000-0003-1865-3192
Karen WongDivision of Gastroenterology, University of Alberta, Edmonton, AB T6G 2X8, Canada.ORCID 0000-0002-5588-2229
Michal GozdzikDivision of Gastroenterology, University of Alberta, Edmonton, AB T6G 2X8, Canada.
Kunihiko OguroDivision of Gastroenterology, University of Alberta, Edmonton, AB T6G 2X8, Canada.ORCID 0000-0002-2267-9304
Todd McMullenDivision of General Surgery, University of Alberta, Edmonton, AB T6G 2X8, Canada.
Brendan HalloranDivision of Gastroenterology, University of Alberta, Edmonton, AB T6G 2X8, Canada.ORCID 0000-0003-0467-1840

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUlcerative colitis (UC) is a chronic, relapsing inflammatory bowel disease that requires regular monitoring. The University of Alberta IBD Unit piloted a proactive outreach protocol for biologic-naïve UC patients, including clinical and biochemical variables, and assessed its impact on UC care.

methodsBiologic-naïve UC patients without follow-up for ≥6 months were recruited by phone and completed Partial Mayo, modified Sutherland Index, and MARS-5 questionnaires, as well as blood work and fecal calprotectin (FCP). Results were sent to each patient's gastroenterologist, who then completed a survey about intended UC management changes.

results81 patients completed the protocol. UC management was changed in 45 (55.6%) cases, with 82.2% of changes being expedited follow-up or management escalation. Six patients had active flares, and 17 with asymptomatic inflammation were identified. 23 patients underwent endoscopy, with 10 (43.4%) showing active disease. Six patients started biologic therapies based on protocol and endoscopic findings. UC management escalations were significantly predicted by FCP and Sutherland Index scores on logistic regression analysis. 86.4% of gastroenterologists rated the protocol helpful.

conclusionsPatient care can be improved by a one-time, proactive outreach program for biologic-naïve UC. Outreach and monitoring in biologic-naïve UC should include assessment of both FCP and clinical markers to improve UC management.

Indexed as

fecal calprotectinremote outreachulcerative colitis

Identifiers

PMID41590218
PMCPMC12839710

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.