ArticleGels (Basel, Switzerland)2025
Development and Characterization of Hollow-Shell Collagen Microcapsules for Three-Dimensional Cell Culture.
Article in Gels (Basel, Switzerland), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Three-dimensional (3D) cell culture systems require biocompatible carriers that provide both structural support and efficient mass transport. Conventional alginate-based encapsulation systems suffer from poor molecular diffusion, lack of cell adhesion motifs, and structural instability under physiological conditions. Here, we report the first development of hollow-shell collagen microcapsules (CMCs) fabricated via a gelatin sacrificial template approach that overcomes these critical limitations. The hollow architecture combined with collagen's intrinsic bioactivity achieved 2.5-fold enhancement in molecular permeability compared to conventional alginate beads, while maintaining structural integrity for 14 days versus 3-day collapse of alginate controls. NIH 3T3 fibroblasts encapsulated within CMCs demonstrated superior proliferation and formed tissue-like multilayered structures with extensive extracellular matrix deposition. This platform represents a significant advance in 3D cell culture technology, providing a biologically functional microenvironment with enhanced mass transport properties for applications in tissue engineering and regenerative medicine.
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