ArticleACS applied materials & interfaces2026
Microbial-Responsive Wound Dressings Based on Biopolymer Degradation Strategy for Detecting Bacterial Infections.
Article in ACS applied materials & interfaces, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed.
- Imaging of biofilms using cryo-scanning electron microscopy.Essays in biochemistry · 2026Review
- Hydrogel-Based Platforms for Wound Care: Integrated Strategies for Antimicrobial Delivery and Biofilm Management.Gels (Basel, Switzerland) · 2026Review
- Smart Dressings for Pre-Ulcer Risk Surveillance and Closed-Loop Chronic Wound Management: Advances, Discrepancies, and Translational Horizons.International journal of nanomedicine · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic wounds remain a major clinical challenge due to their strong association with antibiotic-resistant microbial biofilms. These nonhealing wounds demand advanced therapeutic strategies that go beyond passive protection to actively monitor and respond to changes in the wound environment. To address this, we propose an activity-based sensing strategy that detects bacterial proteolytic activity using composition-tunable biopolymer films that degrade in response to pathogen-secreted enzymes. Gelatin films cross-linked with (3-glycidyloxypropyl)trimethoxysilane (GPTMS) and blended with poly(ethylene oxide) (PEO) were engineered to undergo selective peptide-bond cleavage by proteolytic activity. The incorporation of PEO enhanced water uptake and accelerated enzymatic degradation, with the optimal composition (25% PEO) exhibiting 4-fold faster mass loss compared to cross-linked gelatin, reaching ∼80% degradation within 12-24 h in the presence of the bacterial pathogen
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Registered trials
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