Evidence map›Paper›PMID 41589834›Full record

ArticleeLife2026

Synaptic mechanisms modulate the spatiotemporal dynamics of striatal direct pathway neurons and motor output.

John J Marshall, Jian Xu, Nai-Hsing Yeh, Seongsik Yun, Toshihiro Nomura, John N Armstrong, Jones Parker, Anis Contractor

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

John J MarshallDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Evanston, United States.ORCID https://orcid.org/0000-0002-6481-8413
Jian XuDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Evanston, United States.
Nai-Hsing YehDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Evanston, United States.
Seongsik YunDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Evanston, United States.
Toshihiro NomuraDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Evanston, United States.
John N ArmstrongDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Evanston, United States.
Jones ParkerDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Evanston, United States.ORCID https://orcid.org/0000-0001-9302-1545
Anis ContractorDepartment of Neuroscience, Feinberg School of Medicine, Northwestern University, Evanston, United States.ORCID https://orcid.org/0000-0002-5131-2536

Funding

The role of glutamate receptors in compulsive and perseverative behaviorR01MH099114 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI CONTRACTOR, ANIS · 2012 to 2022
$4.5M
Dopamine, Synaptic Plasticity and Striatal Ensemble Dynamics Underlying Motor LearningR01NS122840 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI PARKER, JONES G · 2021 to 2025
$2.2M
The Neural Basis of Dopamine-Driven Deficits in Cognition and PerceptionR01MH136998 · NIMH · NORTHWESTERN UNIVERSITY · PI Jones G Parker · 2025 to 2026
$1.5M
NIMH NIH HHS R01 MH099114NIMH NIH HHS R01MH099114NIMH NIH HHS R01 MH136998NINDS NIH HHS R01 NS122840
6 · The paper itself

Abstract

Striatal spiny-projection neurons (SPNs) integrate glutamatergic inputs from the motor cortex and thalamus with neuromodulatory signals to regulate motor output. In vivo Ca

Indexed as

Corpus StriatumMotor CortexNeuronsReceptor, Metabotropic Glutamate 5SynapsesAnimalsMedium Spiny NeuronsMiceGrm5 protein, mouseReceptor, Metabotropic Glutamate 5calcium imagingmotor behaviormouseneurosciencestriatum

Identifiers

PMID41589834
PMCPMC12844889

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.