ArticleJACC. Basic to translational science2026
Immune Unresponsiveness to Cardiopulmonary Bypass Is Associated With Unfavorable Outcome in Infants Requiring Cardiac Surgery.
Article in JACC. Basic to translational science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Contributing Factors to Infectious Disease Risk and Vaccine Strategy Optimization in Cardiac Surgery Patients.Vaccines · 2026Review
- Striking the Balance: From Dysregulated Inflammation to Immunoparalysis: Precision Medicine for Pediatric Cardiac Surgery.JACC. Basic to translational science · 2026Article
Corrections and comments
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Authors and funding
15 authors.
Funding
Abstract
Cardiopulmonary bypass (CPB) induces a complex immune response which can lead to complications after pediatric cardiac surgery. We hypothesized that analyzing the whole blood transcriptomic response after cardiac surgery with or without CPB in children would provide new insights into the pathophysiological mechanisms of CPB-related postoperative complications. In this study focusing on infants ≤3 months of age requiring CPB who are more likely to develop postoperative complications, we defined an immune transcriptomic signature related to CPB. Among the genes included in the CPB signature, we identified only 18 genes that were differentially expressed after surgery in patients with a complicated outcome. In contrast, more than 2,000 genes were differentially expressed before and after the surgery in the uncomplicated group. We demonstrated the predictive potential of the preoperative plasma TNFSF12 abundance to identify patients at risk of CPB-induced complications, which was confirmed in an external cohort.
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