Evidence map›Paper›PMID 41589753›Full record

ArticleACS chemical biology2026

Structural and Dynamics Analyses of β-Lactam Inhibition of

Parker L Flanders, Jacob R Gillingham, Carlos Contreras-Martel, Andréa Dessen, Erin E Carlson, Elizabeth A Ambrose

Abstract read
In one paragraph

Article in ACS chemical biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Parker L FlandersDepartment of Medicinal Chemistry, University of Minnesota, 208 Harvard Street SE, Minneapolis, Minnesota 55454, United States.
Jacob R GillinghamDepartment of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, 321 Church St SE, Minneapolis, Minnesota 55454, United States.ORCID 0000-0002-6717-9960
Carlos Contreras-MartelUniv. Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale (IBS), Grenoble F-38044, France.
Andréa DessenUniv. Grenoble Alpes, CNRS, CEA, Institut de Biologie Structurale (IBS), Grenoble F-38044, France.
Erin E CarlsonDepartment of Medicinal Chemistry, University of Minnesota, 208 Harvard Street SE, Minneapolis, Minnesota 55454, United States.ORCID 0000-0001-8287-8893
Elizabeth A AmbroseDepartment of Medicinal Chemistry, University of Minnesota, 208 Harvard Street SE, Minneapolis, Minnesota 55454, United States.ORCID 0000-0003-4275-3513

Funding

Training the Next Generation of Chemical BiologistsT32GM132029 · NIGMS · UNIVERSITY OF MINNESOTA · PI Erin Elizabeth Carlson, William Charles Krause Pomerantz · 2019 to 2026
$2.7M
Chemical Strategies to Map Bacterial Response to Environmental ChangeR35GM153306 · NIGMS · UNIVERSITY OF MINNESOTA · PI Erin Elizabeth Carlson · 2024 to 2026
$1.6M
Spaciotemporal Regulation of Specific Penicillin Binding Protein (PBP) Function Determined by New Activity-Based ApproachesR01GM128439 · NIGMS · UNIVERSITY OF MINNESOTA · PI CARLSON, ERIN ELIZABETH, WINKLER, MALCOLM E. · 2018 to 2019
$936k
NIGMS NIH HHS R01 GM128439NIGMS NIH HHS R35 GM153306NIGMS NIH HHS T32 GM132029
6 · The paper itself

Abstract

The Gram-positive pathogen

Indexed as

Anti-Bacterial Agentsbeta-LactamsPenicillin-Binding ProteinsStreptococcus pneumoniaebeta Lactam AntibioticsCrystallography, X-RayModels, MolecularMolecular Dynamics SimulationProtein ConformationStructure-Activity RelationshipAnti-Bacterial Agentsbeta Lactam Antibioticsbeta-LactamsPenicillin-Binding Proteins

Identifiers

PMID41589753
PMCPMC13032781

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.