Observational studyEuropean journal of neurology2026
Systemic Arterial Stiffness in Reversible Cerebral Vasoconstriction Syndrome: A Prospective Case-Control Study.
Observational study in European journal of neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04463212 (Systemic Endothelial Dysfunction in Reversible Cerebral Vasoconstriction Syndrome), which is not on this map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Systemic Endothelial Dysfunction in Reversible Cerebral Vasoconstriction Syndrome : a Case Control Study
Who cites it
1 citing paper in PubMed.
- Systemic Arterial Stiffness in Reversible Cerebral Vasoconstriction Syndrome: A Prospective Case-Control Study.European journal of neurology · 2026Observational
Corrections and comments
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundReversible cerebral vasoconstriction syndrome (RCVS) is a neurovascular disorder with unclear pathophysiology, particularly concerning systemic endothelial function. Understanding arterial stiffness could shed light on potential systemic vascular involvement in RCVS.
objectiveThis study aimed to investigate systemic endothelial dysfunction in patients with RCVS by assessing arterial stiffness using pulse wave velocity (PWV).
methodsWe conducted a prospective, age- and sex-matched, 1:1 case-control study from January 2020 to January 2023 at Nantes University Hospital. Patients diagnosed with definite RCVS according to ICHD-3 criteria were enrolled as cases; controls were matched individuals without RCVS. All participants underwent PWV measurement as a noninvasive marker of arterial stiffness. Follow-up PWV assessments were performed in RCVS patients at 1 and 3 months after onset.
resultsSixty-two subjects with a mean age of 49.8 years (70% female) were included. One-third of RCVS cases had secondary triggers. Mean systolic and diastolic blood pressures were 130.8 ± 24.0 mmHg and 80.6 ± 1.4 mmHg, respectively, with 29% of patients presenting acute hypertension. No systemic organ dysfunction was observed in cardiac, renal, or hepatic assessments. PWV values at the acute stage showed no significant difference between patients and controls (7.0 vs. 6.4 m.s
conclusionSystemic arterial stiffness, as measured by PWV, remains normal and stable throughout the course of RCVS even during the acute phase and recovery.
trial registrationClinicalTrials.gov, NCT04463212.
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